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  • Brenda A. Wilson, Xinjun Zhu, Mengfei Ho, Luo Lu
  • Biology
  • The Journal of Biological Chemistry
  • 1997 (First Publication: 10 January 1997)
  • Pasteurella multocida toxin (PMT) has been hypothesized to cause activation of a GTP-binding protein (G-protein)-coupled phosphatidylinositol-specific phospholipase C (PLC) in intact cells. We usedExpand
  • Jianbo Dong, Aaron A. Thompson, +7 authors James D Marks
  • Chemistry, Medicine
  • Journal of molecular biology
  • 2010 (First Publication: 9 April 2010)
  • Ingestion or inhalation of botulinum neurotoxin (BoNT) results in botulism, a severe and frequently fatal disease. Current treatments rely on antitoxins, which, while effective, cannot reverseExpand
  • Melissa Pires-Alves, Mengfei Ho, Karla K Aberle, Kim D Janda, Brenda A. Wilson
  • Chemistry, Medicine
  • Toxicon : official journal of the International…
  • 2009 (First Publication: 1 March 2009)
  • The light chain of botulinum neurotoxin A (BoNT/A-LC) is a zinc-metalloprotease that requires two extended exosites for optimal substrate binding and recognition of its intracellular target SNAP25.Expand