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Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives.
TLDR
These findings demonstrate that these phenanthroindolizidine alkaloids and their salt derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.
Therapeutic effects of a novel tylophorine analog, NK-007, on collagen-induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation.
TLDR
It is demonstrated that NK-007 acted on the stability of TNFα messenger RNA and reduced Th17 cell differentiation and significantly inhibited levels of IL-6 and IL-17A in human coculture assay.
A Simple and Efficient Oxidative Coupling of Aromatic Nuclei Mediated by Manganese Dioxide
Oxidative intramolecular coupling of the aryl rings of various stilbenes for direct construction of the phenanthrene ring system is promoted efficiently by manganese dioxide―trifluoroacetic acid at
Design, Synthesis, and Antitobacco Mosaic Virus Activity of Water-Soluble Chiral Quaternary Ammonium Salts of Phenanthroindolizidines Alkaloids.
TLDR
Propargyl quaternary ammonium salt compound S-7b showed the best anti-TMV activities both in vitro and in vivo in the laboratory and in the field trials of antiviral efficacy against TMV, and exhibited better activities than control plant virus inhibitors.
Synthesis of novel tylophorine derivatives and evaluation of their anti-inflammatory activity.
TLDR
34 derivatives of DCB-3503 are synthesized and the anti-inflammatory characteristics of 34 novel tylophorine derivatives are demonstrated and their structure-activity relationship is discussed in order to explore their therapeutic potentials for inflammatory diseases.
Synthesis and antiviral activities of antofine analogues with different C-6 substituent groups.
TLDR
Most of the compounds were found to exhibit higher antiviral activity than commercial Ningnanmycin in vitro and in vivo and the groups with hydrogen donor or electron-withdrawing groups at the C-6 position were foundto be favorable for antiviral action.
Different salt derivatives of phenanthroindolizidine alkaloids display different in vitro antitumor activity
Salification is most commonly employed for modifying physical and chemical properties. However, there are few reports on the differences in biological activity between different salt forms and free
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