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Systematic efforts are underway to decipher the genetic changes associated with tumor initiation and progression. However, widespread clinical application of this information is hampered by an inability to identify critical genetic events across the spectrum of human tumors with adequate sensitivity and scalability. Here, we have adapted high-throughput(More)
Our previous studies have demonstrated that stable microRNAs (miRNAs) in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for diseases, and act as signaling molecules in intercellular communication. Here, we report the surprising finding that exogenous plant miRNAs are present in the sera(More)
Broadly neutralizing monoclonal antibodies (MAbs) are potentially important tools in human immunodeficiency virus type 1 (HIV-1) vaccine design. A few rare MAbs have been intensively studied, but we still have a limited appreciation of their neutralization breadth. Using a pseudovirus assay, we evaluated MAbs from clade B-infected donors and a clade B(More)
The SnRK2 gene family is a group of plant-specific protein kinases that has been implicated in ABA and abiotic stress signaling. We found 11 SnRK2s in maize, assigned names from ZmSnRK2.1 to ZmSnRK2.11 and cloned ten of them. By analyzing the gene structure of all the SnRK2s from Arabidopsis, rice, and maize, we found seven exons that were conserved in(More)
The performance of a generic pedestrian detector may drop significantly when it is applied to a specific scene due to mismatch between the source dataset used to train the detector and samples in the target scene. In this paper, we investigate how to automatically train a scene-specific pedestrian detector starting with a generic detector in video(More)
Target mimicry is a recently identified regulatory mechanism for microRNA (miRNA) functions in plants in which the decoy RNAs bind to miRNAs via complementary sequences and therefore block the interaction between miRNAs and their authentic targets. Both endogenous decoy RNAs (miRNA target mimics) and engineered artificial RNAs can induce target mimicry(More)
GE: Generic detector. SP M(N): Scene detector trained by manually labeling the first N frames out of the total 420 frames. HOG + SVM is used as the detector. (a) Compared with the generic detector, it improves the detection rate from 21% to 62% at 10−6 FPPW. (b) Its performance is comparable with the scene specific detector using 300 manually labeled(More)
Despite a significant growth in the last few years, the availability of 3D content is still dwarfed by that of its 2D counterpart. To close this gap, many 2D-to-3D image and video conversion methods have been proposed. Methods involving human operators have been most successful but also time-consuming and costly. Automatic methods, which typically make use(More)
Recent advances in virtualization technology have made it a common practice to consolidate virtual machines(VMs) into a fewer number of servers. An efficient consolidation scheme requires that VMs are packed tightly, yet receiving resources commensurate with their demands. On the other hand, measurements from production data centers show that the network(More)
The membrane-proximal external region (MPER) of human immunodeficiency virus type 1 (HIV-1) gp41 bears the epitopes of two broadly neutralizing antibodies (Abs), 2F5 and 4E10, making it a target for vaccine design. A third Ab, Fab Z13, had previously been mapped to an epitope that overlaps those of 2F5 and 4E10 but only weakly neutralizes a limited set of(More)