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Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs that leads to profound disability and premature death. To identify new SSc susceptibility loci, we conducted the first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171(More)
The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (lcSSc) and diffuse (dcSSc) cutaneous involvement, and the relationships with presence of the SSc-specific auto-antibodies, anti-centromere (ACA),(More)
Systemic sclerosis (SSc) is complex autoimmune disease affecting the connective tissue; influenced by genetic and environmental components. Recently, we performed the first successful genome-wide association study (GWAS) of SSc. Here, we perform a large replication study to better dissect the genetic component of SSc. We selected 768 polymorphisms from the(More)
1 Introduction This document is a specification of the messages that can be sent by a client or server using the Notification Service Transfer Protocol (NSTP). It is intended to be a complete specification. The document consists of 6 parts: 1. this introduction, 2. a description of the model of service provided by the protocol, 3. assumptions about the(More)
INTRODUCTION CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population. METHODS A total of seven European populations(More)
In the past, rheumatologists may have been perceived by some specialist colleagues as purveyors of toxic drugs for only modest benefits. Some physicians may have had the opinion that we treated complex conditions which were poorly understood with potent drugs whose mechanism of action was largely unknown. The withdrawal of several anti-rheumatic drugs over(More)
Today's mergers and acquisitions (M&As) are increasingly focused on the user experience and design expertise they bring to the acquiring entity. This panel will share vignettes based on personal M&A experiences that provide suggestions and recommendations for user experience teams on both the acquiring and acquired side of the table. The areas of(More)
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