Menaka C Thounaojam

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MicroRNAs (miRNAs) are single-stranded noncoding regions of approximately 21 nucleotides that regulate protein synthesis by targeting mRNAs for translational repression or degradation at the post-transcriptional level. These classes of RNAs are highly conserved across species and are known to regulate several protein-coding genes in humans. Therefore, their(More)
Microglia are the resident macrophages of the CNS, which secrete several pro- and anti-inflammatory cyto-chemokines including interleukin-1β (IL-1β), in response to pathogenic stimuli. Once secreted, IL-1β binds to IL-1 receptor present on microglia and initiates the production of inflammatory cytokines in microglia. However, the detailed information(More)
Japanese encephalitis virus (JEV), a single-stranded RNA (ssRNA) virus, is the leading cause of encephalitis in Asia. Microglial activation is one of the key events in JEV-induced neuroinflammation. Although the various microRNAs (miRNAs) has been shown to regulate microglia activation during pathological conditions including neuroviral infections, till(More)
The hepatoprotective potential of standardized Feronia limonia (Family, Rutaceae) methanolic extract (FL-7) and chloroform soluble fraction (FL-9) were assessed against carbon tetrachloride (CCl4) induced oxidative stress and hepatotoxicity in rats. Rats treated with CCl4 recorded significant elevation in plasma markers of hepatic injury, alteration in(More)
The present study was aimed to evaluate the anti-inflammatory potentials of Vespa tropica (VT) venom and its isolated peptides. Effects of whole venom and its two peptides (Vt1512 and Vt1386) on lipopolysaccharide (LPS) challenged BV-2 murine microglial cells was evaluated. Mouse microglial cell line, BV-2 and crude venom extract as well as purified(More)
Sida rhomboidea. Roxb leaf extract (SRLE) is being used by the populace of North-East India to alleviate symptoms of diabetes and obesity. We have previously reported its hypolipidemic and anti-diabetic properties. In this study, we report the effect of SRLE on (i) in vivo modulation of genes controlling high fat diet (HFD) induced obesity and (ii) in vitro(More)
Globally, the incidence of obesity, metabolic syndrome, and diabetes (OMD) are continuously on the rise because of rapid changes in human lifestyle and dietary habits. Herbal extracts are of special interest in treating combination of these diseases because of their multipronged mode of action. The list of potential herbals to control metabolic diseases is(More)
Japanese encephalitis virus (JEV) predominantly infects neurons and causes damage to the central nervous system (CNS). Neural stem/progenitor cells (NSPCs) constitute multi-potent stem cell population in postnatal/adult brain, with capacity to differentiate into neurons, astrocytes or oligodendrocytes. NSPCs are known to play a pivotal role in CNS repair(More)
The present study was aimed at evaluating protective role of Eugenia jambolana seed extract (EJSE) on high cholesterol diet (HCD) induced hyperlipidemia/hypercholesterolemia amounting to cardiac and hepatic oxidative stress. Serum markers of cardiac and hepatic damage, total lipid profile (serum, tissue and feces), lipid peroxidation, antioxidant status and(More)
The prevalence of obesity, metabolic syndrome, and type 2 diabetes is continuously on rise due to modernization of life style and changing dietary habits. Use of herbal medicines for the treatment of metabolic diseases is a viable option and list of potential candidates is ever expanding. This 2016 edition of this special issue regarding natural products(More)