Melle J. W. van der Molen

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Developmental changes in background EEG power spectra were examined in 5-12-year-old children. The results confirmed older and more recent studies that reported continuous maturation and more sudden growth spurts in power spectral amplitude. EEG power in the Delta and Theta frequency bands decreased gradually with age, while power in the Alpha and Beta(More)
The present study investigated the mechanisms underlying reductions in the susceptibility to interference from irrelevant information that are evident in the developing child. In the first experiment, where the task was to focus on one stimulus dimension and to ignore a second dimension, variations in the degree of spatial integration in multidimensional(More)
We examined two potential inhibitory mechanisms for stopping a motor response. Participants performed a standard visual two-choice task in which visual stop signals and no-go signals were presented on a small proportion of the trials. Psychophysiological measures were taken during task performance to examine the time course of response activation and(More)
When children grow older they respond faster and are less susceptible to interference caused by task-irrelevant information. These observations suggested the hypothesis that a global mechanism may account for developmental change in the speed of responding and that inhibitory function may underlie the ability to activate speeded responses. The current study(More)
Forty-nine adolescents performed the Wisconsin Card Sorting Test (WCST). A main PCA component of WCST performance was identified as 'efficiency of reasoning'. This factor was related to feedback processing. From the WCST, a perseveration score can be derived. Perseveration is the continued application of a rule, after it has been disconfirmed. We compared(More)
OBJECTIVE This study examined whether attention deficits in fragile X syndrome (FXS) can be traced back to abnormalities in basic information processing. METHOD Sixteen males with FXS and 22 age-matched control participants (mean age 29 years) performed a standard oddball task to examine selective attention in both auditory and visual modalities. Five FXS(More)
OBJECTIVE The present study investigated involuntary change detection in a two-tone pre-attentive auditory discrimination paradigm in order to better understand the information processing mechanisms underlying attention deficits in fragile X syndrome (FXS) males. METHODS Sixteen males with the FXS full mutation and 20 age-matched control participants(More)
BACKGROUND Previous research into working memory of individuals with intellectual disabilities (ID) has established clear deficits. The current study examined working memory in children with mild ID (IQ 55-85) within the framework of the Baddeley model, fractionating working memory into a central executive and two slave systems, the phonological loop and(More)
Disruptions in functional connectivity and dysfunctional brain networks are considered to be a neurological hallmark of neurodevelopmental disorders. Despite the vast literature on functional brain connectivity in typical brain development, surprisingly few attempts have been made to characterize brain network integrity in neurodevelopmental disorders. Here(More)
The objective of this study was to investigate the effects of methylphenidate (MPH) on attention and inhibition in children with Attention Deficit Hyperactivity Disorder (ADHD) and to establish what the relative contributions of the noradrenergic and dopaminergic systems to this effect were. In addition to MPH, two other drugs were administered in order to(More)