Melita A Charles

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Background—Abdominal (visceral) and overall obesity are both related to coronary heart disease mortality risk; however, the relative contribution of these 2 components of fat deposit in the etiology of sudden death is unknown. Methods and Results—We used the data from 7079 asymptomatic men of the Paris Prospective Study I who were free of ischemic heart(More)
OBJECTIVE Fine-needle aspiration biopsy (FNAB) is the preferred diagnostic study for evaluating thyroid nodules. Despite its accuracy, many patients undergo thyroidectomy for benign nodules. This study was undertaken to identify risk factors that might increase the specificity of FNAB. METHODS Medical records of 422 patients who underwent thyroid surgery(More)
BACKGROUND Clinically palpable thyroid nodules are present in approximately 10% of the population, although only 5% to 7% of these nodules harbor malignancy. Fine-needle aspiration has become one of the central tools in the diagnostic armamentarium of the surgeon/endocrinologist. There is, however, up to a 30% indeterminate diagnostic rate associated with(More)
To analyse the cost-effectiveness ratio of screening for microalbuminuria in diabetic patients using either dipstick tests or laboratory assays, 506 diabetic patients were screened for microalbuminuria using both a traditional laboratory assay (strategy I) or a laboratory assay only in the case of a positive dipstick result (strategy II). Dipstick(More)
The diagnosis of ventricular tachycardia is pmarily dependent upon the demonstration of dissociated atrial and ventricular activity. When retrograde conduction remains intact in patients with ventricular tachycardia, preserving a I: i relation between the ventricles and the atria, the diagnosis cannot be established in the usual fashion. This report(More)
The integrity of the blood-retinal and blood-glomerular vascular barriers were investigated simultaneously in diabetic individuals to determine whether or not the early forms of diabetic retinopathy and nephropathy are temporally related. The blood-retinal barrier was assessed by the technique of vitreous fluorophotometry. Twenty-four hour urinary excretion(More)
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