• Publications
  • Influence
An Amino-Terminal Polo Kinase Interaction Motif Acts in the Regulation of Centrosome Formation and Reveals a Novel Function for centrosomin (cnn) in Drosophila
TLDR
A Cnn and PoloKinase interaction is apparently required during embryogenesis and involves the exon 1A-initiating coding exon, suggesting a subset of Cnn splice variants is regulated by Polo kinase.
Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster
TLDR
This work systematically examined deficiencies of the left arm of chromosome 2 and characterize gene-by-gene dosage responses that vary from collapsed expression through modest partial dosage compensation to full or even over compensation, suggesting that cases of gene regulation due to altered nuclear architecture are rare.
Centrosomin: A Complex Mix of Long and Short Isoforms Is Required for Centrosome Function During Early Development in Drosophila melanogaster
TLDR
This study addresses several questions surrounding Cnn function at the centrosome during embryogenesis and shows that cnn function cannot be ascribed to a single protein.
The end of a monolith: Deconstructing the Cnn-Polo interaction
TLDR
Immunoprecipitation experiments show that Cnn-LF interacts directly with mitotically activated Polo kinase and requires the 2 phosphorylation sites in Exon1A, the initiating exon of a subset of Cnn isoforms, and show that a view of cnn as encoding a single peptide is too simplistic.
Genome-wide expression profiling Drosophila melanogaster deficiency heterozygotes reveals diverse genomic responses
TLDR
It is found that the transcriptional dose response is generally varied, gene-specific, and coherently propagates into gene expression regulatory networks, suggesting that there is little effect of nuclear architecture and long-range enhancer and/or silencer promoter contact on gene expression in the compact Drosophila genome.