Melissa Metzler

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The urinary excretion and metabolic pattern of 17 beta-trenbolone, a synthetic anabolic steroid hormone used as a growth promotor for beef cattle in several countries, has been studied in a human subject. For the separation of the metabolites of 17 beta-trenbolone, a reversed-phase high-performance liquid chromatographic method was established. The method(More)
Purpose. The aim of this study was to characterize the intracellular fate and nuclear uptake kinetics of oligonucleotides (ON) that were complexed with protamine sulfate (PS) and negatively charged liposomes at different ratios of ON to PS. Methods. Double-fluorescence labelling of ON and liposomal lipid was applied to simultaneously monitor the interaction(More)
The metabolism of the animal growth promotants diethylstilbestrol, zeranol and 17 beta-trenbolone and of a few anabolizing steroids used in humans is briefly reviewed. The possible role of reactive metabolic intermediates in the toxicity of some anabolic agents is discussed. Analytical implications of the metabolism of anabolizing agents are described and(More)
Die Behandlung krebskranker Kinder und Jugendlicher wurde innerhalb der letzten 50 Jahre stetig verbessert, mit dem Ergebnis, dass heute Überlebensraten von etwa 75% erreicht werden. Chemo- und/oder Radiotherapien können allerdings bei bis zu 2/3 der Patienten Folgeerkrankungen (Spätfolgen) verursachen. Anthrazyklininduzierte Kardiotoxizität,(More)
In male patients with congenital anomalies of the kidney and urinary tract, an increased incidence of a polymorphism in the angiotensin type 2 receptor gene (AT2R) has been identified. The AT2R has been shown to be involved in apoptosis, particularly during embryogenesis. The aim of this study was to examine the A→1675G transition polymorphism in intron 1(More)
DOI 10.1007/s00347-013-2881-3 Online publiziert: 5. Juli 2013 © Springer-Verlag Berlin Heidelberg 2013 A.I. Berta1 · N. Naumann-Bartsch2 · A. Agaimy3 · M. Metzler2 · F.E. Kruse1 · L. Holbach1 1 Augenklinik mit Poliklinik, Universitätsklinikum Erlangen, Universität Erlangen-Nürnberg, Erlangen 2 Klinik für Kinderund Jugendmedizin, Universität(More)
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