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Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.
Conjugation of CPP to PMO enhances the PMO pharmacokinetic profile, tissue uptake, and subsequent retention, and when dosed at < or = 15 mg/kg, CPP is a promising transporter for enhancing PMO delivery in therapeutic settings. Expand
Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism.
Studies indicate AVI-4557 is an effective and specific inhibitor of CYP3A4 expression and sequence-dependent inhibition of cyclophosphamide-related cytocidal activity in both cell types. Expand
Reduction in tamoxifen‐induced CYP3A2 expression and DNA adducts using antisense technology
Overall the data suggest the utility of antisense technology in the redirection of TAM metabolism thereby lowering TAM genotoxicity in rat liver, and several CYP genes were down regulated. Expand