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Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS).
TLDR
This review examines the use of cluster ion sources and cryogenically compatible sample handling for improved ion yields and to expand the application potential of SIMS. Expand
Chemical intervention in plant sugar signalling increases yield and resilience
TLDR
It is shown that chemical intervention in a potent sugar signal increases grain yield, whereas application to vegetative tissue improves recovery and resurrection from drought, offering a means to combine increases in yield with crop stress resilience. Expand
C60 secondary ion mass spectrometry with a hybrid-quadrupole orthogonal time-of-flight mass spectrometer.
TLDR
The combination of MALDI and SIMS is shown to add capabilities to each technique, providing a robust platform for TOF-SIMS experiments that already exists in a large number of laboratories. Expand
Single-cell imaging mass spectrometry.
TLDR
The availability of proteins and lipids in a single cell is estimated and strategies employed to improve sensitivity at the single-cell level are discussed. Expand
Chemical analysis of single cells.
TLDR
This work presents a meta-analysis of single cell fluorescent imaging techniques using a platform-agnostic approach that automates the very labor-intensive and therefore time-heavy and expensive process of manually cataloging and analyzing individual cells. Expand
Single-cell lipidomics: characterizing and imaging lipids on the surface of individual Aplysia californica neurons with cluster secondary ion mass spectrometry.
TLDR
The ability to detect these molecules and determine their relative distribution on the single-cell level shows that the C(60)-QSTAR is a potential platform for studying important biochemical processes, such as neuron degeneration. Expand
The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power
TLDR
The development of a 3D OrbiSIMS instrument for label-free biomedical imaging and single-cell metabolomic profiling are reported, and it is observed that the upregulation of phospholipid species and cholesterol is correlated with the accumulation of amiodarone. Expand
Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging.
TLDR
Three-dimensional secondary ion mass spectrometry (SIMS) imaging was used to investigate the cellular uptake of the antiarrhythmic agent amiodarone, a phospholipidosis-inducing pharmaceutical compound, and provided the basis for studying Cellular uptake of pharmaceutical compounds and their metabolites on the single cell level. Expand
Fabrication and characterisation of drug-loaded electrospun polymeric nanofibers for controlled release in hernia repair.
TLDR
Increased linear viscoelastic regions observed in the rheometry studies suggest that both irgasan and levofloxacin alter the internal structure of the native polymeric matrix, a potential material for hernia repair mesh. Expand
Electrospun collagen-based nanofibres: A sustainable material for improved antibiotic utilisation in tissue engineering applications.
TLDR
The studies did show that collagen helped shift both drugs into sustained release behaviour, and ideal modifications to electrospun scaffolds may prove useful in further research regarding the acceptance of human tissue by inhibiting the potential for bacterial infection. Expand
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