Melissa K. Hartley

Learn More
PURPOSE (1) To determine the radiographic correction/healing rate, patient-reported outcomes, reoperation rate, and complication rate after distal femoral osteotomy (DFO) for the valgus knee with lateral compartment pathology. (2) To summarize the reported results of medial closing wedge and lateral opening wedge DFO. METHODS We conducted a systematic(More)
A diverse subset of pattern recognition receptors (PRRs) detects pathogen-associated nucleic acids to initiate crucial innate immune responses in host organisms. Reflecting their importance for host defense, pathogens encode various countermeasures to evade or inhibit these immune effectors. PRRs directly engaged by pathogen inhibitors often evolve under(More)
PURPOSE Pegloticase-associated adverse events reported to the Food and Drug Administration Adverse Event Reporting System (FAERS) database in the United States were evaluated. METHODS Retrospective data-mining analysis of FAERS case reports listing Krystexxa or pegloticase as the suspect drug and specific adverse events (cardiovascular events,(More)
PURPOSE To quantify the reported failures and reoperations for the emerging technique of matrix-assisted cartilage repair at short-term and midterm follow-up. METHODS We conducted a systematic review of 3 databases from March 2004 to February 2014 using keywords important for articular cartilage repair. Two authors reviewed the articles, the study(More)
BACKGROUND Articular cartilage has minimal endogenous ability to undergo repair. Multiple chondral restoration strategies have been attempted with varied results. QUESTIONS/PURPOSES The purpose of our review was to determine: (1) Does articular chondrocyte transplantation or matrix-assisted articular chondrocyte transplantation provide better(More)
ACKNOWLEDGMENT This monograph is based on the papers and discussion from a technical review on " Molecular Approaches to Drug Abuse Research " held on August 24-25, 1989, in Bethesda, MD. The review meeting was sponsored by the National Institute on Drug Abuse. The National Institute on Drug Abuse has obtained permission from the copyright holders to(More)
  • 1