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OBJECTIVE To update the 2008 American Academy of Neurology (AAN) guidelines regarding botulinum neurotoxin for blepharospasm, cervical dystonia (CD), headache, and adult spasticity. METHODS We searched the literature for relevant articles and classified them using 2004 AAN criteria. RESULTS AND RECOMMENDATIONS Blepharospasm: OnabotulinumtoxinA(More)
BACKGROUND/AIMS To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD). METHODS HR-QOL measured by the Parkinson Disease Quality of Life Questionnaire (PDQ-39), MCI according to Movement Disorder Society Task Force criteria and cognitive decline from premorbid(More)
We examined the frequency of Parkinson disease with mild cognitive impairment (PD-MCI) and its subtypes and the accuracy of 3 cognitive scales for detecting PD-MCI using the new criteria for PD-MCI proposed by the Movement Disorders Society. Nondemented patients with Parkinson's disease completed a clinical visit with the 3 screening tests followed 1 to 3(More)
BACKGROUND Patient engagement in clinical practice guideline (CPG) development is recommended by multiple institutions and instruments measuring guideline quality. Approaches to engaging patients, however, vary between oversight organizations, quality tools and guideline developers. OBJECTIVE We propose a ten-step framework outlining steps and options for(More)
Ricinus communis was used to test the Ben Zioni-Dijkshoorn hypothesis that NO(3) uptake by roots can be regulated by NO(3) assimilation in the shoot. The rate of the anion charge from assimilated NO(3) (-) (and SO(4) (2-)) was followed in its distribution between organic acid anion accumulation and HCO(3) (-) efflux into the nutrient solution. In plants(More)
OBJECTIVE To develop an evidence-based guideline assessing pharmacologic options for treating Huntington disease (HD) chorea. METHODS We evaluated available evidence from a structured literature review performed through February 2011. RESULTS AND RECOMMENDATIONS If HD chorea requires treatment, clinicians should prescribe tetrabenazine (up to 100(More)
OBJECTIVE To discuss the American Academy of Neurology (AAN)'s Top Five Recommendations in the Choosing Wisely campaign promoting high-value neurologic medicine and physician-patient communication. The AAN published its Top Five Recommendations in February 2013 in collaboration with the American Board of Internal Medicine Foundation and Consumer Reports. (More)
Growing evidence suggests that perioperative withdrawal of ASA for secondary stroke prevention increases thromboembolic risk without the associated benefit of decreased bleeding complications. ASA maintenance is acceptable in many procedures, including invasive ones. Many procedures, in particular ophthalmologic, dermatologic, and dental surgeries, also are(More)
INTRODUCTION Few objective data exist regarding predictors of leaving the workforce (LWF) in Parkinson's disease (PD). METHODS Employed PD patients were followed prospectively. Baseline demographics, disease duration, and measures of disease severity, cognition, disability, and mental health were compared between patients working at last follow-up versus(More)
BACKGROUND Recently, symptoms similar to addictive drug withdrawal have been reported in a structured longitudinal study of patients with idiopathic Parkinson's Disease (PD) withdrawing from dopamine agonists (DA): the dopamine agonist withdrawal syndrome (DAWS). OBJECTIVES The objective of this study was to establish the frequency, predictors, and(More)