Melissa Hamm

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The brain's serotonergic system centrally regulates several physiological processes and its dysfunction has been implicated in the pathophysiology of several neuropsychiatric disorders. While in the past our understanding of serotonergic neurotransmission has come mainly from mouse models, the development of pluripotent stem cell and induced(More)
Introduction: Estimates of metabolites in the brain using large-FOV chemical shift imaging (CSI) are severely hampered by strong lipid signals even though the interfering signal arises from subcutaneous tissue. Since SNR in MR is proportional to voxel size [1] the low metabolite concentration, and therefore low SNR in spectroscopic imaging dictates large(More)
An international team that included 20 independent laboratories from biopharmaceutical companies, universities, analytical contract laboratories and national authorities in the United States, Europe and Asia was formed to evaluate the reproducibility of sample preparation and analysis of N-glycans using capillary electrophoresis of(More)
This false color image illustrates the diverse contributions of human serotonergic neurons to neuropsychiatric and mood disorders, which may now be studied using transdifferentiated human serotonergic neurons. (Top left to bottom right) The panel shows iSNs immunopositive for tryptophan hydroxylase, serotonin and the neuronal marker MAP2ab, and an overlay(More)
The structure of the upper layer of a comet is a product of its surface activity. The Rosetta Lander Imaging System (ROLIS) on board Philae acquired close-range images of the Agilkia site during its descent onto comet 67P/Churyumov-Gerasimenko. These images reveal a photometrically uniform surface covered by regolith composed of debris and blocks ranging in(More)
The N-linked glycosylation in recombinant monoclonal antibodies (mAb) occurs at Asn297 on the Fc region in the CH2 domain. Glycosylation heterogeneities have been well documented to affect biological activities such as antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) through their interaction with Fc-receptors.(More)
  • Arrondo G, Alegre M, Sepulcre J, Iriarte J, Artieda J, Villoslada P +50 others
  • 2012
Abnormalities in brain synchronization are correlated with cognitive impairment in multiple sclerosis. A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles. of trabecular structure analysis using flat-panel volume computed tomography. Quantitative relationship between coronary calcium content and coronary(More)
Estimation of the electrical parameters of spinal motoneurons using impedance measurements. Electrical parameters of spinal motoneurons were estimated by optimizing the parameters of motoneuron models to match experimentally determined impedance functions with those of the models. The model was described by soma area, somatic and dendritic membrane(More)
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