Melissa Freedenberg

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Systems biology models and simulation tools are critical components for bridging molecular biology with predictive medicine. We report a systematic comparison of popular simulation tools, including CellDesigner, COPASI and VirtualCell, to facilitate translational research in genomics, proteomics and systems biology. Different tools evaluating the same model(More)
Emerging applications for positron emission tomography (PET) may require the ability to image very low activity source distributions in the body. The performance of clinical PET scanners in the regime where activity in the field of view is <1 MBq has not previously been explored. In this study, we compared the counting rate performance of two clinical(More)
Studies have implicated ceramide as a key molecular agent in regulating programmed cell death, or apoptosis. Consequently, there is significant potential in targeting intracellular ceramide as a cancer therapeutic agent. The cell's major ceramide source is the ceramide de novo synthesis pathway, which consists of a complex network of interdependent(More)
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