Melissa C Lutterodt

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In rodents, the Otx2 gene is expressed in the diencephalon, mesencephalon, and cerebellum and is crucial for the development of these brain regions. Together with Otx1, Otx2 is known to cooperate with other genes to develop the caudal forebrain and, further, Otx1 is also involved in differentiation of young neurons of the deeper cortical layers. We have(More)
We studied the spatial and temporal expression of the homeobox genes PAX6, OTX2, and OTX1 using a developmental series of human fetal eyes aged from 6 to 10 weeks post-conception. Previous animal studies have shown that PAX6 may regulate progenitor cell proliferation, timing of differentiation and neural retina cell fate determination. OTX2 may play a role(More)
The development of the human neocortex is a complex and highly regulated process involving a time-related expression of many transcription factors including the homeobox genes Pax6 and Meis2. During early development, Pax6 is expressed in nuclei of radial glia cells in the neocortical proliferative zones and controls the differentiation and neurogenetic(More)
The aim of this study was to investigate the spatiotemporal development of autonomic nerve fibers and primordial germ cells (PGCs) along their migratory route from the dorsal mesentery to the gonadal ridges in human embryos using immunohistochemical markers and electron microscopy. Autonomic nerve fibers in the dorsal mesentery, the pre-aortic and(More)
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