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Stretch‐stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP‐kinase
Alternatives to the canonical insulin‐stimulated pathway for glucose uptake are exercise‐ and exogenous reactive oxygen species (ROS)‐stimulated glucose uptake. We proposed a model wherein mechanicalExpand
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TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling.
Murine models of starvation-induced muscle atrophy demonstrate that reduced protein kinase B (AKT) function upregulates the atrophy-related gene atrogin-1/MAFbx (atrogin). The mechanism involvesExpand
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Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice*
Acid sphingomyelinase plays important roles in ceramide homeostasis, which has been proposed to be linked to insulin resistance. To test this association in vivo, acid sphingomyelinase deletionExpand
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Interleukin-1 stimulates catabolism in C2C12 myotubes.
Interleukin-1 (IL-1) is an inflammatory cytokine that has been linked to muscle catabolism, a process regulated by muscle-specific E3 proteins of the ubiquitin-proteasome pathway. To address cellularExpand
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Physical inactivity and muscle weakness in the critically ill
Patients in the intensive care unit commonly develop muscle weakness. In part, this reflects loss of mechanical loading due to physical inactivity, bed rest, or immobilization. Mechanical unloadingExpand
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Prion protein expression and functional importance in skeletal muscle.
UNLABELLED Skeletal muscle expresses prion protein (PrP) that buffers oxidant activity in neurons. AIMS We hypothesize that PrP deficiency would increase oxidant activity in skeletal muscle andExpand
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Objective: 22q11.2 Deletion syndrome (22q11.2DS) is the most common chromosome deletion syndrome and increases the risk of autoimmune conditions, including thyroid disease, cytopenias, and juvenileExpand