Melissa A. Pynnonen

Learn More
OBJECTIVES To identify significant clinical and pathological predictors of survival in mucosal melanoma of the head and neck. DESIGN Retrospective case series. We reviewed cases of mucosal melanoma of the head and neck from a prospectively collected database after institutional review board approval. SETTING A single academic institution. PATIENTS(More)
Staphylococcus aureus nasal colonization is an important risk factor for community and nosocomial infection. Despite the importance of S. aureus to human health, molecular mechanisms and host factors influencing nasal colonization are not well understood. To identify host factors contributing to nasal colonization, we collected human nasal secretions and(More)
OBJECTIVE To determine if isotonic sodium chloride (hereinafter "saline") nasal irrigations performed with large volume and delivered with low positive pressure are more effective than saline sprays at improving quality of life and decreasing medication use. DESIGN A prospective, randomized controlled trial. SETTING Community. PARTICIPANTS A total of(More)
BACKGROUND The microbiota of the nares has been widely studied. However, relatively few studies have investigated the microbiota of the nasal cavity posterior to the nares. This distinct environment has the potential to contain a distinct microbiota and play an important role in health. RESULTS We obtained 35,142 high-quality bacterial 16S rRNA-encoding(More)
BACKGROUND Patients with chronic rhinosinusitis are cared for by multiple specialties. Endoscopy and imaging are important diagnostic tools. However, because physicians vary in their access to imaging and endoscopy, testing may vary across specialties. The purpose of this study is to characterize differences in use of imaging and endoscopy between(More)
OBJECTIVE To compare the prevalence of acute sinusitis (AS) and chronic sinusitis (CS) diagnosed by primary care and emergency medicine physicians in our academic institution to national data. STUDY DESIGN Cross-sectional pilot study of institutional census data and a population-based national sample. The setting was primary care and emergency departments(More)
  • 1