Melissa A Hilmes

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BACKGROUND The kidneys are a site of extramedullary leukemic disease that can be readily detected by CT. OBJECTIVE To demonstrate the spectrum of CT findings in children with renal leukemic involvement. MATERIALS AND METHODS Twelve children were identified retrospectively as having renal leukemic involvement by contrast-enhanced CT of the abdomen.(More)
DNA polymerase alpha-primase is known to be phosphorylated in human and yeast cells in a cell cycle-dependent manner on the p180 and p68 subunits. Here we show that phosphorylation of purified human DNA polymerase alpha-primase by purified cyclin A/cdk2 in vitro reduced its ability to initiate simian virus 40 (SV40) DNA replication in vitro, while(More)
OBJECTIVE Childhood interstitial lung diseases (ILD) occur in a variety of clinical contexts. Advances in the understanding of disease pathogenesis and use of standardized terminology have facilitated increased case ascertainment. However, as all studies have been performed at specialized referral centers, the applicability of these findings to general(More)
OBJECTIVE The purpose of our study was to evaluate the diagnostic efficacy and impact of emergent MRI after recent intervention in children with suspected osteomyelitis or septic arthritis. MATERIALS AND METHODS This retrospective case-control study in children with suspected osteomyelitis or septic arthritis consisted of 34 study subjects (mean age, 5.3(More)
PURPOSE Hepatoblastoma is commonly unresectable at presentation, necessitating induction chemotherapy before definitive resection. To refine the paradigm for timing of resection, we questioned whether a plateau in hepatoblastoma responsiveness to neoadjuvant therapy could be detected by calculating tumor volume (TV) and serum alpha-fetoprotein (sAFP)(More)
AIMS This study harnessed the electronic medical record to assess pancreas volume in patients with type 1 diabetes (T1D) and matched controls to determine whether pancreas volume is altered in T1D and identify covariates that influence pancreas volume. METHODS This study included 25 patients with T1D and 25 age-, sex-, and weight-matched controls from the(More)
The Society of Uroradiology (SUR) advances genitourinary tract imaging, image guided interventions, and the study of the normal and abnormal genitourinary tract as a clinical specialty. The Society therefore has specific interest in all aspects of the practice of genitourinary tract imaging, including the training of physicians for such clinical practice.(More)
BACKGROUND Chest CT after pediatric trauma is frequently performed but its clinical impact, particularly with respect to surgical intervention, has not been adequately evaluated. OBJECTIVE To assess the impact of chest CT compared with chest radiography on pediatric trauma management. MATERIALS AND METHODS Two hundred thirty-five consecutive pediatric(More)