Melisa L. Budde

Justin M Greene3
Thomas C Friedrich3
David H O’Connor2
Brian T Cain2
Ngoc H Pham2
3Justin M Greene
3Thomas C Friedrich
2David H O’Connor
2Brian T Cain
2Ngoc H Pham
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Live-attenuated vaccination with simian immunodeficiency virus (SIV) SIVmac239Deltanef is the most successful vaccine product tested to date in macaques. However, the mechanisms that explain the efficacy of this vaccine remain largely unknown. We utilized an ex vivo viral suppression assay to assess the quality of the immune response in(More)
A small percentage of human immunodeficiency virus (HIV)-infected people and simian immunodeficiency virus (SIV)-infected macaques control virus replication without antiretroviral treatment. The major determinant of this control is host expression of certain major histocompatibility complex alleles. However, this association is incompletely penetrant,(More)
CD8+ T cell responses, restricted by major histocompatibility complex (MHC) class I molecules, are critical to controlling human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) replication. Previous studies have used MHC-matched siblings and monozygotic twins to evaluate genetic and stochastic influences on HIV-specific T cell(More)
PRED mafa is a computational system for prediction of peptide binding to three transcriptionally abundant major histocompatibility complex (MHC) class I alleles of Mauritian cynomolgus macaque, an important animal model for the study of human disease. The prediction system utilizes quantitative matrices, which were validated using experimentally determined(More)
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