Melinda L. Allott

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BACKGROUND The Drosophila neoplastic tumor suppressor Lethal (2) giant larvae (Lgl) controls apicobasal cell polarity and proliferation. We have previously shown that lgl(-) clones in the developing eye exhibit ectopic proliferation and suppress apoptosis without affecting apicobasal cell polarity. Ectopic expression of the apical polarity regulators(More)
The junctional neoplastic tumour suppressors, Lgl, Dlg and Scrib, function in apical-basal cell polarity and limiting cell proliferation. In homozygous lgl, dlg or scrib mutants over-proliferation and polarity loss occurs in the larval imaginal disc epithelium. However, in lgl mutant mosaic eye epithelium, ectopic Cyclin E expression and cell proliferation(More)
phology. We have generated a Tg(phd3:GFP)/+; vhl1/+ transgenic line, which exhibit robust GFP expression in the vhl1/vhl1 background , essentially acting as an in vivo fluorescent reporter to identify the mutant cells/embryos. To induce VHL kidney tumors in fish, we have utilized this transgenic line to generate donor embryos and transplanted the mutant(More)
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