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BACKGROUND The Drosophila neoplastic tumor suppressor Lethal (2) giant larvae (Lgl) controls apicobasal cell polarity and proliferation. We have previously shown that lgl(-) clones in the developing eye exhibit ectopic proliferation and suppress apoptosis without affecting apicobasal cell polarity. Ectopic expression of the apical polarity regulators(More)
phology. We have generated a Tg(phd3:GFP)/+; vhl1/+ transgenic line, which exhibit robust GFP expression in the vhl1/vhl1 background , essentially acting as an in vivo fluorescent reporter to identify the mutant cells/embryos. To induce VHL kidney tumors in fish, we have utilized this transgenic line to generate donor embryos and transplanted the mutant(More)
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