Melanie Schwenk

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BACKGROUND Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomonocytic cells into the vessel wall, and stimulates both vascular and inflammatory cell NADPH oxidases. The predominant source of reactive oxygen species, eg, vascular (endothelial, smooth muscle, adventitial) versus phagocytic NADPH oxidase, and(More)
BACKGROUND Interaction between vascular wall abnormalities, inflammatory leukocytes, platelets, coagulation factors and hemorheology in the pathogenesis of deep vein thrombosis (DVT) is incompletely understood, requiring well defined animal models of human disease. METHODS AND RESULTS We subjected male C57BL/6 mice to ligation of the inferior vena cava(More)
OBJECTIVE Immune cells contribute to angiotensin II (ATII)-induced vascular dysfunction and inflammation. Interferon-γ (IFN-γ), an inflammatory cytokine exclusively produced by immune cells, seems to be involved in ATII-driven cardiovascular injury, but the actions and cellular source of IFN-γ remain incompletely understood. APPROACH AND RESULTS(More)
CD40 ligand (CD40L) is involved in the vascular infiltration of immune cells and pathogenesis of atherosclerosis. Additionally, T cell CD40L release causes platelet, dendritic cell and monocyte activation in thrombosis. However, the role of CD40L in angiotensin II (ATII)-driven vascular dysfunction and hypertension remains incompletely understood. We tested(More)
IFN-α is an antineoplastic agent in the treatment of several solid and hematologic malignancies that exerts strong immune- and autoimmune-stimulating activity. However, the mechanisms of immune activation by IFN-α remain incompletely understood, particularly with regard to CD4(+)CD25(high)Foxp(+) regulatory T cells (Treg). Here, we show that IFN-α(More)
Motiviert durch die Frage, wie sich Verständnis innerhalb eines Gesprächs unter Studenten bei der gemeinsamen Bearbeitung von Lernmaterial entwickelt, entstand der Wunsch, diese Gespräche möglichst automatisiert auswerten zu können, um so zukünftig mögliche Probleme bei der Bearbeitung von Aufgabenstellungen in studienbegleitenden Laboren vorzubeugen. Dazu(More)
Background—Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomono-cytic cells into the vessel wall, and stimulates both vascular and inflammatory cell NADPH oxidases. The predominant source of reactive oxygen species, eg, vascular (endothelial, smooth muscle, adventitial) versus phagocytic NADPH oxidase, and(More)
IFN-a is an antineoplastic agent in the treatment of several solid and hematologic malignancies that exerts strong immuneand autoimmune-stimulating activity. However, themechanisms of immune activation by IFN-a remain incompletely understood, particularly with regard to CD4þCD25highFoxpþ regulatory T cells (Treg). Here, we show that IFN-a deactivates the(More)
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