Melanie Schwenk

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BACKGROUND Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomonocytic cells into the vessel wall, and stimulates both vascular and inflammatory cell NADPH oxidases. The predominant source of reactive oxygen species, eg, vascular (endothelial, smooth muscle, adventitial) versus phagocytic NADPH oxidase, and(More)
Freshly isolated liver cells of guinea pig were used to study the metabolism of NDMA in the concentration range 0.05 to 100 microM. Analysis was performed using the gas chromatograph-thermal energy analyzer nitrosamine detector method and with radiolabeled NDMA. At concentrations below 10 microM, NDMA was degraded by liver cells (10 mg of protein in 2.5 ml(More)
IFN-a is an antineoplastic agent in the treatment of several solid and hematologic malignancies that exerts strong immune-and autoimmune-stimulating activity. However, the mechanisms of immune activation by IFN-a remain incompletely understood, particularly with regard to CD4 þ CD25 high Foxp þ regulatory T cells (Treg). Here, we show that IFN-a deactivates(More)
Background—Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomono-cytic cells into the vessel wall, and stimulates both vascular and inflammatory cell NADPH oxidases. The predominant source of reactive oxygen species, eg, vascular (endothelial, smooth muscle, adventitial) versus phagocytic NADPH oxidase, and(More)
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