Melanie Merk

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Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that also modulates physiologic cell signaling pathways. MIF is expressed in cardiomyocytes and limits cardiac injury by enhancing AMPK activity during ischemia. Reperfusion injury is mediated in part by activation of the stress kinase JNK, but whether MIF modulates JNK in this(More)
Measurement of ψ(2S) meson production in pp collisions at √ s = 7 TeV Abstract The differential cross-section for the inclusive production of ψ(2S) mesons in pp collisions at √ s = 7 TeV has been measured with the LHCb detector. The data sample corresponds to an integrated luminosity of 36 pb −1. The ψ(2S) mesons are reconstructed in the decay channels(More)
  • S Amato, D Carvalho, P Colrain, T Da Silva, J R T De Mello, L De Paula +494 others
  • 2000
This Technical Design Report is dedicated to Tom Ypsilantis. Tom conceived the Ring Imaging Cherenkov detectors for particle identification in LHCb and he made an inestimable contribution to the LHCb RICH project. Tom would have wished to see these detectors in operation. He was totally dedicated to the project. He will be missed by the RICH group for his(More)
Using pp collision data corresponding to an integrated luminosity of 1.0 fb(-1) and collected by LHCb in 2011 at a center-of-mass energy of 7 TeV, we report the measurement of direct CP violation in B(s)(0)→K(-)π(+) decays, A(CP)(B(s)(0)→K(-)π(+)=0.27±0.04 (stat)±0.01 (syst), with significance exceeding 5 standard deviations. This is the first observation(More)
The macrophage migration inhibitory factor (MIF)-homologue D-dopachrome tautomerase (D-DT) recently has been described to have similar functions as MIF. However, the role of D-DT, as opposed to MIF, in tumor biology remains unknown. We hypothesized that D-DT could represent a target for therapeutic interventions in cancer. We analyzed the production of D-DT(More)
  • Aachen-Antwerp, Brussels-Berlin, Zeuthen )-Helsinki-Krakow-Mosco W-Nijmegen-Rio De, Janeiro-Serpukhov-Warsaw-Yerevan M Adamus, N M Agababyan, I V Ajinenko +47 others
  • 2007
The charged particle multiplicity distribution has been studied for non-single-diiractive + p and pp collisions at p s = 22 GeV, for full phase space as well as for intervals in rapidity, azimuthal angle and transverse momentum. In general, the multiplicity distribution is well described by a negative binomial. From comparison of the distribution for(More)
Resonant structures in B^{0}→ψ^{'}π^{-}K^{+} decays are analyzed by performing a four-dimensional fit of the decay amplitude, using pp collision data corresponding to 3  fb^{-1} collected with the LHCb detector. The data cannot be described with K^{+}π^{-} resonances alone, which is confirmed with a model-independent approach. A highly significant(More)
An angular analysis of the decay J /ψ → μ + μ − is performed to measure the polarization of prompt J /ψ mesons produced in pp collisions at √ s = 7 TeV. The dataset corresponds to an integrated luminosity of 0.37 fb −1 collected with the LHCb detector. The measurement is presented as a function of transverse momentum, p T , and rapid-ity, y, of the J /ψ(More)
A search for the rare decays B(s)(0)→μ+ μ- and B(0)→μ+ μ- is performed with data collected in 2011 and 2012 with the LHCb experiment at the Large Hadron Collider. The data samples comprise 1.1  fb(-1) of proton-proton collisions at sqrt[s]=8  TeV and 1.0  fb(-1) at sqrt[s]=7  TeV. We observe an excess of B(s)(0)→μ+ μ- candidates with respect to the(More)
The angular distributions and the partial branching fraction of the decay B0 → K*0 μ+ μ- are studied by using an integrated luminosity of 0.37  fb(-1) of data collected with the LHCb detector. The forward-backward asymmetry of the muons, A(FB), the fraction of longitudinal polarization, F(L), and the partial branching fraction dB/dq2 are determined as a(More)