Melanie L Brimson

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OBJECTIVE The goal of this study was to investigate the relationship between default mode network connectivity and the severity of post-traumatic stress disorder (PTSD) symptoms in a sample of eleven acutely traumatized subjects. METHOD Participants underwent a 5.5 min resting functional magnetic resonance imaging scan. Brain areas whose activity(More)
Chronic cocaine exposure has been associated with progressive brain structural and functional changes. Clarifying mechanisms underlying cocaine's progressive brain effects may help in the development of effective cocaine abuse treatments. We used a controlled squirrel monkey model of chronic cocaine exposure (45 mg/kg/week for 9 months) combined with(More)
Chronic cocaine abusers experience brain and peripheral vascular dysfunction, the severity of which tends to be greater in men than women. The mechanisms underlying these effects of cocaine are unknown. Because nitric oxide (NO) abnormalities play key roles in development of vascular dysfunction in several disorders, we determined whether vascular nitric(More)
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