Melanie-Jayne R. Howes
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Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders.
In traditional practices of medicine, numerous plants have been used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's disease (AD) and other memory related… Expand
Acetylcholinesterase Inhibitors from Plants and Fungi
Acetylcholinesterase inhibitors from plants and fungi.
- P. Houghton, Yuhao Ren, Melanie-Jayne R. Howes
- Chemistry, Medicine
- Natural product reports
- 29 March 2006
This review describes 183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase. The mechanism of action of cholinesterase, together with the binding sites,… Expand
Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function
In traditional practices of Ayurvedic and Chinese medicine, numerous plants have been used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer's disease (AD). An… Expand
Natural Products and Derivatives Affecting Neurotransmission Relevant to Alzheimer’s and Parkinson’s Disease
The two major neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterised by low levels in the brain of the neurotransmitters acetylcholine (ACh) and dopamine… Expand
Natural products as a source of Alzheimer's drug leads.
This review focuses on recent developments in the use of natural products as therapeutics for Alzheimer's disease. The compounds span a diverse array of structural classes and are organized according… Expand
A Double-Blind Placebo-Controlled Randomized Trial of Melissa officinalis Oil and Donepezil for the Treatment of Agitation in Alzheimer’s Disease
Background/Aims: Behavioural and psychological symptoms (BPSD) are frequent in people with Alzheimer’s disease and cause considerable stress to patients and their carers. Antipsychotics have been… Expand
Medicinal Plants and Dementia Therapy: Herbal Hopes for Brain Aging?
An escalating "epidemic” of diseases like Alzheimer's has not yet been met by effective symptomatic treatments or preventative strategies. Among a few current prescription drugs are cholinesterase… Expand
Metabolomic analysis of saponins in crude extracts of Quillaja saponaria by liquid chromatography/mass spectrometry for product authentication.
- G. Kite, Melanie-Jayne R. Howes, M. S. Simmonds
- Chemistry, Medicine
- Rapid communications in mass spectrometry : RCM
- 15 December 2004
Analysis of 50% aqueous methanolic extracts of bark of Quillaja saponaria Molina (quillaja) by liquid chromatography/mass spectrometry (LC/MS), using negative ion electrospray, revealed over 100… Expand
Novel diterpenoid acetylcholinesterase inhibitors from Salvia miltiorhiza.
- Yuhao Ren, P. Houghton, R. Hider, Melanie-Jayne R. Howes
- Medicine, Chemistry
- Planta medica
- 1 March 2004
Acetylcholinesterase (AChE, EC 22.214.171.124) inhibitors are the only registered drugs used to treat Alzheimer's disease (AD). New AChE inhibitors may contribute to the design of new pharmaceuticals and… Expand