Melanie H Champion

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BACKGROUND Cytomegalovirus (CMV) transfusion-transmitted disease (TTD) remains a clinical concern. Universal leukoreduction has become one of the main strategies for the prevention of CMV-TTD. Through prospective clinical follow-up and testing of transfusion recipients (TRs), the risk for CMV-TTD was studied. STUDY DESIGN AND METHODS Transfused units were(More)
BACKGROUND Between January 1995 and November 1998, at Yale-New Haven Hospital, 25 percent of RBCs transfused were processed through prestorage or bedside leukoreduction filters, chosen on a per patient basis (selective leukoreduction [SLR]). Between January 1995 and July 1999, 30 percent of platelet concentrates (PCs) were infused through bedside(More)
BACKGROUND The goal of this study was to assess transfusion reactions arising from prestorage-pooled platelet (PSPP) infusions compared with apheresis single-donor platelets (SDPs) and poststorage-pooled, whole blood-derived random-donor platelets (RDPs). STUDY DESIGN AND METHODS Over a span of 18 months, transfusion reaction records of patients receiving(More)
Threats to national and local blood supplies in America mandate development of an effective blood management system for emergency preparedness and efficient blood inventory management. Seasonal or acute blood shortages could be compounded by the unavoidable distribution inefficiencies of the blood pipeline during an emergency. The Yale-New Haven Hospital(More)
  • K Tadokoro, H W Reesink, +17 authors M H Champion
  • Vox sanguinis
  • 2010
In Japan, where all cell concentrates are irradiated because of an unusually high risk of transfusion-associated graft-versus-host disease (GVHD) due to the high percentage of HLA homozygous subjects in the population, there have been problems with the breakdown of IBL gamma irradiators. When an irradiator breaks down, it is often found to be difficult for(More)
BACKGROUND There have been few recent systematic studies of blood recipients for direct evidence of blood safety, especially for emerging pathogens that may pose a threat to the blood supply. STUDY DESIGN AND METHODS Recipients who would likely require transfusion from multiple donors were recruited and a blood specimen was collected before their first(More)
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