Melanie Hümmelgen

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Arterial hypotension can cause cerebral ischemia when the autoregulation of the cerebral circulation is exhausted. We hypothesized that sudden cerebral vasoconstriction induced by moderate hypotensive, but hemodynamically stable, sustained ventricular tachycardias (MHT-VT) further compromises cerebral blood flow (CBF) and induces an ischemic stress response(More)
Ischemia-reperfusion-induced injury of the coronary vasculature could result in an attenuated vasodilator or increased vasoconstrictor tone that might impact on myocardial recovery and viability. In 30 open-chest dogs the left circumflex coronary artery was occluded for 15 or 60 min and then reperfused, and responses to intracoronary acetylcholine, the(More)
ings on the ointment-treated site and the untreated site, was comparedbetweenthepositiveandthenegative treatmenthistory groups. In addition, functional magnetic resonance imaging (fMRI)wasperformed to assess pain-relatedbrain activity as a physiologicalmeasure of analgesia. Specifically,we tested whether the difference in pain-related responses between the(More)
AIM This study was performed to compare the myocardial uptake of Tc-99m-furifosmin (Q12) versus Tc-99m-sestamibi (MIBI) in correlation to the whole-body uptake under resting conditions. METHODS 21 patients with coronary artery disease and no rest ischemia were examined. A whole-body scan was performed 60 min. p.i. under resting conditions. A(More)
HISTORY AND CLINICAL FINDINGS A 78-year-old patient experienced dizziness, impairment of mnemic and cognitive function, chronic fatigue and recurrent syncope. INVESTIGATIONS Hypertensive heart disease, reduced left ventricular function, and ventricular ectopia classification Lown IVb was documented. Computed tomography showed minimal brain atrophia.(More)
BACKGROUND Attenuation of myocardial stunning by several angiotensin-converting enzyme (ACE) inhibitors has been demonstrated. However, the signal cascade mediating such protective effect has not been analyzed in detail so far. METHODS AND RESULTS In a first protocol, we addressed the role of bradykinin and analyzed the effect of the ACE inhibitor(More)
We report on a male, 31 year old, Turkish patient with an intracardiac mass in the right ventricle, reduction of performance and weight, as well as intermittent fever. No eosinophilia was documented in the peripheral blood; cardiac function was primarily normal. Besides the differential diagnosis of Löffer's endocarditis (endomyocardial fibrosis) an(More)
Wir berichten über einen 31jährigen türkischen Patienten mit einer rechtskardialen Raumforderung, Leistungsminderung, Gewichtsabnahme und intermittierenden Fieberschüben. Im peripheren Blut bestand keine Eosinophilie, die kardiale Funktion war primär unauffällig. Neben einer Endokarditis fibroplastica Löffler bestand differentialdiagnostisch der Verdacht(More)
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