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Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI:…
- Victoria J. B. Gotham, Melanie C. Hobbs, Ryan N Burgin, D. Turton, C. Smythe, I. Coldham
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 7 January 2016
A new route to a tetracyclic lactam was developed and the product, called VG1, was found to inhibit nonsense-mediated mRNA decay at μM concentrations.
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay†
A significant proportion of genetic diseases, as well as many cancers, are associated with a particular type of mutation which gives rise to a premature termination codon (PTC) before the genuine… Expand
Highly Enantioselective Metalation-Substitution alpha to a Chiral Nitrile
We report the deprotonation of a chiral nitrile and reaction of the resulting chiral organometallic species with a variety of electrophiles to give highly enantiomerically enriched 2-substituted… Expand
Frequency of change of diagnoses in first‐episode psychosis
Early diagnosis leading to relevant treatment and appropriate psychoeducation is crucial to the role of an early intervention in psychosis (EIP) team. However, diagnostic uncertainty in first‐episode… Expand