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- Publications
- Influence
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay† †Electronic supplementary information (ESI) available: Experimental procedures and spectroscopic data. See DOI:…
- Victoria J. B. Gotham, Melanie C. Hobbs, Ryan N Burgin, D. Turton, C. Smythe, I. Coldham
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 7 January 2016
A new route to a tetracyclic lactam was developed and the product, called VG1, was found to inhibit nonsense-mediated mRNA decay at μM concentrations.
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay†
A significant proportion of genetic diseases, as well as many cancers, are associated with a particular type of mutation which gives rise to a premature termination codon (PTC) before the genuine… Expand
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Highly Enantioselective Metalation-Substitution alpha to a Chiral Nitrile
- I. Coldham, A. M. Meijer, Arghya Sadhukhan, Melanie C. Hobbs
- Materials Science
- 2017
We report the deprotonation of a chiral nitrile and reaction of the resulting chiral organometallic species with a variety of electrophiles to give highly enantiomerically enriched 2-substituted… Expand
Frequency of change of diagnoses in first‐episode psychosis
- Melanie C. Hobbs, Rachel Stanbrook, N. Chakraborty
- Medicine
- 1 March 2017
Early diagnosis leading to relevant treatment and appropriate psychoeducation is crucial to the role of an early intervention in psychosis (EIP) team. However, diagnostic uncertainty in first‐episode… Expand