Melanie-Anne John

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BACKGROUND Data from Kwazulu Natal, South Africa, suggest that almost all patients with extensively drug-resistant (XDR) tuberculosis are HIV-positive, with a fatal outcome. Since, there are few data for the treatment-related outcomes of XDR tuberculosis in settings with a high HIV prevalence, we investigated the associations of these diseases in such(More)
The reliability of clinical signs that might be used by village health workers in distinguishing acute lower respiratory infection (LRI) from upper respiratory infections (URI) in children was evaluated. 142 infants and 108 preschool children with LRI and 151 infants and 281 preschool children with URI, attending hospital, were studied. Respiratory rates of(More)
BACKGROUND The shortage of doctors and nurses, along with future expansion into rural clinics, will require that the majority of clinic visits by HIV infected patients on antiretroviral therapy (ART) are managed by non-doctors. The goal of this study was to develop and evaluate a screening protocol to determine which patients needed a full clinical(More)
To the Editor: Tuberculosis (TB) is the leading cause of illness and death among HIV-1–infected patients in sub-Saharan Africa (1–3), but valid data on the population-level interaction between the TB and HIV epidemics are scarce (4). Our objective was to determine the extent of this dual epidemic in our setting, a hospital in Johannesburg, South Africa. We(More)
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