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Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions in DNA and RNA is(More)
Accumulation of β-amyloid (Aβ) peptide in the brain is a major hallmark of Alzheimer's disease. An optimal brain insulin level promotes Aβ clearance, which may play protective roles against Alzheimer's disease. In this study we examined the role of dietary conditions leading to insulin resistance on amyloidosis in fructose-drinking rats. Further(More)
DNA lesions in mammalian cells may be induced by reactive oxygen species, alkylation, and ionizing radiation. This damage can then be repaired via the base excision repair (BER) pathway, which includes single strand break repair (SSBR). Thus, the BER (SSBR) pathway plays a critical role in maintaining genomic integrity, and may help us to better understand(More)
O121 Table 1. Baseline patients characteristics based on randomization arm (interim 96-week population n 254) ATV/r 3TC (DT arm) n 126 ATV/r 2NRTIs (TT arm) n 128 p Age, years 43.4 (35.7 49.2) 44.2 (36.2 51.0) 0.963 Male gender 107 (84.9) 96 (75.0) 0.069 IDU (risk factor) 8 (6.3) 11 (8.6) 0.659 HCV co-infection 12 (9.5) 14 (10.9) 0.836 Previous AIDS events(More)
BACKGROUND Long acting antiretroviral drugs represent a promising approach for chronic treatment of HIV infection. Here, we study the efficacy and safety of albuvirtide (ABT), an HIV-1 fusion inhibitor with a half life of 11-12 days in human. METHODS ABT was evaluated in a 7-week, open-label and randomized trial, combining with LPV/r. Twenty(More)
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