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Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity
TLDR
The results assigned an unconventional role to T6SSs, which will lay the foundation for studying novel mechanisms of metal ion uptake by bacteria and the role of this process in their resistance to host immunity and survival in harmful environments. Expand
Manganese scavenging and oxidative stress response mediated by type VI secretion system in Burkholderia thailandensis
TLDR
The contact-independent functions of T6 SS for metal acquisition and bacteria–bacteria competition, reported here, suggest that T6SS may have been retrofitted by some bacteria to gain additional adaptive functions during evolution and provide a perspective for understanding the mechanisms of metal ion uptake and the roles of T 6SS in bacteria– bacteria competition. Expand
The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition.
TLDR
It is found that HmuR is a redox-regulated dual-functional transporter that transports heme iron under normal conditions but zinc upon sensing extracellular oxidative stress, triggered by formation of an intramolecular disulfide bond. Expand
Functional characterization of a mycothiol peroxidase in Corynebacterium glutamicum that uses both mycoredoxin and thioredoxin reducing systems in the response to oxidative stress.
TLDR
The MPx function is investigated by examining its potential peroxidase activity using different proton donors and it is proposed that the C. glutamicum MPx represents a new type of GPx that uses both mycoredoxin and Trx systems for oxidative stress response. Expand
Physiological roles of mycothiol in detoxification and tolerance to multiple poisonous chemicals in Corynebacterium glutamicum
TLDR
It is found that intracellular MSH contributes significantly to resistance to alkylating agents, glyphosate, ethanol, antibiotics, heavy metals and aromatic compounds, and is beneficial for withstanding oxidative stress induced by various oxidants in C. glutamicum. Expand
Functional characterization of a vanillin dehydrogenase in Corynebacterium glutamicum
TLDR
The vdh deletion mutant partially lost its ability to grow on vanillin, indicating the presence of alternative VDH(s) in Corynebacterium glutamicum and contributes to understanding the VDH diversity from bacteria and the aromatic metabolism pathways in C. glutamum. Expand
NrdH Redoxin Enhances Resistance to Multiple Oxidative Stresses by Acting as a Peroxidase Cofactor in Corynebacterium glutamicum
TLDR
Evidence is presented that the NrdH redoxin can protect against the damaging effects of reactive oxygen species (ROS) induced by various exogenous oxidative stresses by acting as a peroxidase cofactor. Expand
Overexpression of Mycothiol Disulfide Reductase Enhances Corynebacterium glutamicum Robustness by Modulating Cellular Redox Homeostasis and Antioxidant Proteins under Oxidative Stress
TLDR
Results indicate that the Mtr protein functions in C. glutamicum by protecting cells against oxidative stress, thus maintaining intracellular redox homeostasis. Expand
Corynebacterium glutamicum Methionine Sulfoxide Reductase A Uses both Mycoredoxin and Thioredoxin for Regeneration and Oxidative Stress Resistance
TLDR
It is reported that a Corynebacterium glutamicum methionine sulfoxide reductase A (CgMsrA) that belongs to the 3-Cys family of MsrAs plays important roles in oxidative stress resistance. Expand
Mycothiol protects Corynebacterium glutamicum against acid stress via maintaining intracellular pH homeostasis, scavenging ROS, and S-mycothiolating MetE.
TLDR
Evidence is presented that MSH confers C. glutamicum with the ability to adapt to acidic conditions by maintaining pHi homeostasis, scavenging reactive oxygen species (ROS), and protecting methionine synthesis by the S-mycothiolation modification of Methionine synthase (MetE). Expand
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