Meirav Apel-Paz

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Surfactant partitioning into lipid vesicles was studied using isothermal titration calorimetry (ITC), comparing the behavior of four surfactants with current or potential application in contraception and the prevention of sexually transmitted diseases: nonoxynol-9 (N-9), the amphoteric mixture known as C31G, benzalkonium chloride (BZK), and sodium dodecyl(More)
We studied surfactant-induced leakage of vesicles, comparing the efficacy of four surfactants with current or potential application in contraception and the prevention of sexually transmitted diseases: nonoxynol-9 (N-9); the amphoteric mixture known as C31G; benzalkonium chloride (BZK); sodium dodecyl sulfate (SDS). Several features are generic to the(More)
We have presented a series of lipid constructs as models of the sperm plasma membrane. We also isolated the plasma membrane from rabbit sperm cells and characterized the lipid composition. The behavior of these various membrane systems was evaluated using a vesicle leakage assay, in which surfactant (nonoxynol-9, N-9; or benzalkonium chloride, BZK) exposure(More)
Vesicle leakage experiments were carried out to establish how cholesterol content regulates membrane permeability as induced by surfactant exposure. Vesicles containing up to 50% cholesterol were examined. Four different surfactants were chosen as membrane perturbants, including nonoxynol-9 which is commonly used in spermicidal formulations. As part of this(More)
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