Meiling Lu

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Pathogenesis and growth of three common women's cancers (breast, endometrium and ovary) are linked to estrogen. A single gene encodes the key enzyme for estrogen biosynthesis named aromatase, inhibition of which effectively eliminates estrogen production in the entire body. Aromatase inhibitors successfully treat breast cancer, whereas their roles in(More)
XRCC1 plays a central role in mammalian single-strand break repair. Although it has no enzymatic activity of its own, it stimulates the activities of polynucleotide kinase/phosphatase (PNKP), and this function is enhanced by protein kinase CK2 mediated phosphorylation of XRCC1. We have previously shown that non-phosphorylated XRCC1 stimulates the kinase(More)
maintained in these splice variants, suggesting that they encode 80†" 85-kDa BRCA)-derived proteins composed of the amino and ca.rboxyl portions of full-length BRCA1 protein. Thus, alternative transcripts of BRCAJ encode for proteins that lack approximately 60% of the internal amino acids that make up full-length BRCA1. The ubiquitous expression of these(More)
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