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Functional neuroimaging studies have found intra-regional activity and inter-regional connectivity alterations in patients with post-traumatic stress disorder (PTSD). However, the results of these studies are based on group-level statistics and therefore it is unclear whether PTSD can be discriminated at single-subject level, for instance using the machine(More)
This study aims to investigate the neurostructural foundations of the human personality in young adults. High-resolution structural T1-weighted MR images of 71 healthy young individuals were processed using voxel-based morphometric (VBM) approach. Multiple regression analyses were performed to identify the associations between personality traits and gray(More)
OBJECTIVE The network hubs, characterized by the large number of connections to other regions, play important roles in the proper and effective transfer of information. Previous functional neuroimaging studies have demonstrated that patients with social anxiety disorder (SAD) have aberrant functional connectivity. The changing pattern in functional network(More)
We previously report that BMP2 mediates mild ER stress-activated ATF6 and directly regulates XBP1S splicing in the course of chondrogenesis. The mammalian unfolded protein response (UPR) protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER). Failure to adapt to ER stress causes the UPR to trigger apoptosis. The(More)
Noninvasive localization of brain function is used to understand and treat neurological disease, exemplified by pre-operative fMRI mapping prior to neurosurgical intervention. The principal approach for generating these maps relies on brain responses evoked by a task and, despite known limitations, has dominated clinical practice for over 20years. Recently,(More)
Post-traumatic stress disorder (PTSD) is a psychiatric disorder that occurs in individuals who have experienced life-threatening mental traumas. Previous neuroimaging studies have indicated that the pathology of PTSD may be associated with the abnormal functional integration among brain regions. In the current study, we used functional connectivity density(More)
BACKGROUND A large number of previous neuroimaging studies have explored the functional alterations of post-traumatic stress disorder (PTSD). However, abnormalities in the functional architecture of resting-state networks in PTSD were rarely elucidated. METHODS This study used independent component analysis to explore the resting-state intranetwork and(More)
Growth Arrest and DNA Damage-inducible 45 (Gadd45) and MDM2 proteins, together with p21 and p53, play important roles in cell cycle checkpoints, DNA repair, and genome integrity maintenance. Gadd45 and MDM2 were activated and transcribed instantly by UV irradiation, whereas blueberry anthocyanins (BA) decreased the gene and protein expression levels in(More)
BACKGROUND Recent studies on resting-state functional magnetic resonance imaging (fMRI) have found an abnormal temporal correlation between low-frequency oscillations (LFO) in social anxiety disorder (SAD). However, alterations in the amplitudes of these LFO remain unclear. METHODS This study included 20 SAD patients and 20 age-, gender-, and(More)
As is well known, the Greedy Ensemble Pruning (GEP) algorithm, also called the Directed Hill Climbing Ensemble Pruning (DHCEP) algorithm, possesses relatively good performance and high speed. However, because the algorithm only explores a relatively small subspace within the whole solution space, it often produces suboptimal solutions of the ensemble(More)