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Construction and evaluation of a novel humanized HER2-specific chimeric receptor
TLDR
The results of this study show that novel chA21 scFv-based, HER2-specific CAR T cells not only recognized and killed HER2+ breast and ovarian cancer cells ex vivo but also induced regression of experimental breast cancer in vivo.
Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
TLDR
This work shows how zebrafish can be used to study how host contributions can facilitate metastasis at its earliest stages, and reveals a new macrophage-dependent mechanism of metastasis with possible prognostic implications.
A Significant Statistical Advancement on the Predictive Values of ERCC1 Polymorphisms for Clinical Outcomes of Platinum-Based Chemotherapy in Non-Small Cell Lung Cancer: An Updated Meta-Analysis
TLDR
Current evidence strongly indicated the prospect of ERCC1 C118T and C8092A as predictive biomarkers for platinum-based chemotherapy in Asian NSCLC patients, however, the results should be interpreted with caution and large prospective studies are still required to further investigate these findings.
Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects
TLDR
A structural overview of the development of CAR technology is provided and critical issues related to CAR therapy are discussed, including the optimization of CAR T cells, the route of administration, CAR toxicity and the blocking of inhibitory molecules.
Antitumor effects and persistence of a novel HER2 CAR T cells directed to gastric cancer in preclinical models.
TLDR
The results provide the basis for the future clinical investigation of the humanized chA21 scFv based, 4-1BB costimulated CAR T cells for the treatment of gastric cancer, and other HER2-expressing solid tumors.
Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy
TLDR
It is shown that orally active capecitabine at an extremely low and nontoxic dose displays a potent antiangiogenic effect that can be used for maintenance therapy, and this findings provide a rationalized concept of effective cancer therapy by long-term maintenance of AAD-triggered antiANGiogenic effects with orally active, nontoxic, low-cost, clinically available chemotherapeutics.
APOBEC3 deletion increases the risk of breast cancer: a meta-analysis
TLDR
It is indicated that APOBEC3 copy number variations might have a good screening accuracy for breast cancer.
Association of angiotensin I converting enzyme insertion/deletion polymorphism with breast cancer: a meta-analysis
TLDR
The meta-analysis suggests that ACE I/D polymorphism may not be a genetic risk factor for breast cancer.
B7-H3 expression in ductal and lobular breast cancer and its association with IL-10.
TLDR
High B7-H3 expression in human breast cancer tissues may be important in tumor progression and invasiveness, and this expression appeared to be correlated with the ability of B7 -H3 to promote IL-10 secretion.
Association between Angiotensin II Type 1 Receptor Gene Polymorphisms and Ischemic Stroke: A Meta-Analysis
TLDR
The present meta-analysis suggests that the AT1R gene A1166C polymorphisms are not associated with susceptibility to ischemic stroke.
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