Meilan Liu

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BACKGROUND Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for human cancer therapy, prostate cancer still remains resistant to TRAIL. Both X-linked inhibitor of apoptosis (XIAP) and nuclear factor-kappaB function as key negative regulators of TRAIL signaling. In this study, we evaluated the effect of SH122, a(More)
Using a high-throughput screening (HTS) approach, we have identified and validated several small-molecule Mcl-1 inhibitors (SMI). Here, we describe a novel selective Mcl-1 SMI inhibitor, 2 (UMI-77), developed by structure-based chemical modifications of the lead compound 1 (UMI-59). We have characterized the binding of UMI-77 to Mcl-1 by using complementary(More)
PURPOSE While effective targeted therapies exist for estrogen receptor-positive and HER2-positive breast cancer, no such effective therapies exist for triple-negative breast cancer (TNBC); thus, it is clear that additional targets for radiosensitization and treatment are critically needed. EXPERIMENTAL DESIGN Expression microarrays, qRT-PCR, and Western(More)
Urotensin II (UII) induces the development of cardiac remodeling and atherosclerosis by promoting hypertrophy of cardiomyocytes and mitogenesis of fibroblasts and vascular smooth muscle cells. But its effect on cardiac side population cells (CSPs), one of somatic stem cells, is unclear. The present study examined the influences of UII on the differentiation(More)
PURPOSE The molecular drivers of metastasis in breast cancer are not well understood. Therefore, we sought to identify the biological processes underlying distant progression and define a prognostic signature for metastatic potential in breast cancer. EXPERIMENTAL DESIGN In vivo screening for metastases was performed using Chick Chorioallantoic Membrane(More)
This thesis is about the investigation of the geometrically nonlinear responses and bulging factors of cracked laminated composite cylindrical shell structures subjected to internal pressure. Hybrid strain based three-node flat triangular shell elements, developed by To and Wang were used. Effects of dynamic responses of various numbers of layers and their(More)
PURPOSE An unmet clinical need in breast cancer management is the accurate identification of patients who will benefit from adjuvant radiotherapy. We hypothesized that integration of postradiation clonogenic survival data with gene expression data across breast cancer cell (BCC) lines would generate a radiation sensitivity signature (RSS) and identify(More)
Using a high-throughput screening (HTS) approach, we have identified and validated several small-molecule Mcl-1 inhibitors (SMI). Here, we describe a novel selective Mcl-1 SMI inhibitor, 2 (UMI-77), developed by structure-based chemical modifications of the lead compound 1 (UMI-59). We have characterized the binding of UMI-77 to Mcl-1 by using complementary(More)
This article presents a numerical simulation that aims to examine the effect, of randomness in forward speed, in lateral clearance (dead band) and in both, on the dynamic behaviors of single-and two-axle railway wheelsets. Randomness is represented by pseudo-random numbers. They are incorporated into the dynamic models of the wheelsets. Subsequently, the(More)
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