• Publications
  • Influence
The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila
De-ubiquitylating enzymes (DUBs) reverse protein ubiquitylation and thereby control essential cellular functions. Screening for a DUB that counteracts caspase ubiquitylation to regulate cellExpand
  • 7
  • 2
Ubiquitin-mediated regulation of apoptosis.
Ubiquitin is a protein modifier that is conjugated to target proteins either as a single moiety or as polyubiquitin chains. Over the past several years, an increasing number of ubiquitin ligases andExpand
  • 77
  • 1
Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis.
Cell death and inflammation are ancient processes of fundamental biological importance in both normal physiology and human disease pathologies. The recent observation that apoptosis regulatoryExpand
  • 11
  • 1
Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease.
Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin (HTT) gene, translating into an elongated polyglutamine stretch. In addition to the neurotoxic mutant HTT protein, theExpand
  • 6
  • 1
  • Open Access
M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila
Post-translational modifications such as ubiquitination play a key role in regulation of inflammatory nuclear factor-κB (NF-κB) signalling. The Drosophila IκB kinase γ (IKKγ) Kenny is a centralExpand
  • 24
  • Open Access
TRIAD3/RNF216 E3 ligase specifically synthesises K63-linked ubiquitin chains and is inactivated by mutations associated with Gordon Holmes syndrome
TRIAD3/RNF216 is a ubiquitin ligase of the RING-in-between-RING family. Recent publications identified TRIAD3 mutations in patients with neurological diseases, including Gordon Holmes syndrome andExpand
  • 4
Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family
Understanding function and specificity of de-ubiquitylating enzymes (DUBs) is a major goal of current research, since DUBs are key regulators of ubiquitylation events and have been shown to beExpand
  • 5
New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules
ABSTRACT Mechanisms that regulate the formation of membrane-less cellular organelles, such as neuronal RNA granules and stress granules, have gained increasing attention over the past years. TheseExpand
  • 4
Nerve‐racking – apoptotic and non‐apoptotic roles of caspases in the nervous system of Drosophila
Studies using Drosophila as a model system have contributed enormously to our knowledge of caspase function and regulation. Caspases are best known as central executioners of apoptosis but alsoExpand
  • 4
Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth*
Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that is highly conserved in animals and plants. CRBN proteins have been implicated in various biological processes such asExpand
  • 2