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Cumulative cortisol burden is known to influence neuropsychiatric and metabolic disorders. To better understand the relationship between daily cortisol exposure and measures of the diurnal circadian… Continue Reading
Collection of salivary cortisol has become increasingly popular in large population-based studies. However, the impact of protocol compliance on day-to-day reliabilities of measures, and the extent… Continue Reading
4Background: Andecaliximab (ADX) is a monoclonal antibody that inhibits matrix metalloproteinase 9, an extracellular enzyme involved in matrix remodeling, tumor growth, and metastasis. A phase I/Ib… Continue Reading
Bilateral adrenal neoplasms are very rare. Studies have shown that most are metastatic tumors, and clinical presentation varies with tumor type. We retrospectively reviewed medical records of 18… Continue Reading
OBJECTIVE To investigate the association between salivary cortisol and two markers of subclinical cardiovascular disease (CVD), coronary calcification (CAC), and ankle-brachial index (ABI). METHODS… Continue Reading
4033Background: GS-5745 is a monoclonal antibody that inhibits matrix metalloproteinase 9 (MMP9), an extracellular enzyme involved in matrix remodeling, tumor growth, and metastasis. Preclinical st...
OBJECTIVE To study the contribution of genetic factors to the variance of serum leptin concentration in healthy, normotensive twins. METHODS A total of 57 pairs of twins were investigated: 28… Continue Reading
OBJECTIVE Detecting the loss of heterozygosity in paraffin-embedded pancreatic cancer tissues. METHODS Analysing loss of heterzygosity (LOH) of microsatellite DNA on chromosome loci 3,5,7,9 and 18… Continue Reading
e13584 Background: Entospletinib (ENTO/GS-9973) is an orally bioavailable, selective, reversible, small molecule spleen tyrosine kinase (Syk) inhibitor. ENTO is currently in a Phase 2 clinical tria...