Meihong Ren

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BACKGROUND Idiopathic congenital talipes equinovarus (ICTEV) is a congenital limb deformity. Based on extended transmission disequilibrium testing, Gli-Kruppel family member 3 (Gli3) has been identified as a candidate gene for ICTEV. Here, we verify the role of Gli3 in ICTEV development. METHODS Using the rat ICTEV model, we analyzed the differences in(More)
OBJECTIVE To conduct genetic testing and prenatal diagnosis for a pregnant women with growth retardation, severe mental retardation, and a history of adverse pregnancies. METHODS G-banded chromosome analysis, fluorescence in situ hybridization (FISH), and whole genome DNA microarray were used to analyze the patient and her fetus. RESULTS The women was(More)
OBJECTIVE To perform prenatal diagnosis for a fetus with multiple malformations. METHODS The fetus was subjected to routine karyotyping and whole genome microarray analysis. The parents were subjected to high-resolution chromosome analysis. RESULTS Fetal ultrasound at 28+4 weeks has indicated intrauterine growth restriction, left kidney agenesis, right(More)
OBJECTIVE To investigate the genetic cause and prognosis of a fetus with a rare karyotype. METHODS Fluorescence in situ hybridization (FISH) was used for verifying a structural chromosomal abnormality detected by conventional karyotyping analysis. Whole genome DNA microarray was used to analyze copy number variations carried by the fetus. RESULTS The(More)
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