Meifang Huang

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The intestinal microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD), and geographical and genetic backgrounds impact the composition of the intestinal microbiota. However, there is a lack of evidence regarding the overall changes and characteristics of fecal-associated microbiota (FAM) and mucosa-associated microbiota(More)
To establish the risk factors for initial surgery in patients with Crohn’s disease (CD) in Central China. The subjects of this study were patients with CD treated at Zhongnan Hospital of Wuhan University, an IBD center in Wuhan City, Central China, between January, 1992 and June, 2012. We conducted uni- and multivariate analyses of the risk factors for(More)
Biological agents have been widely used in the treatment of Crohn’s disease (CD). These drugs carry the risk of excessive immunosuppression, indicating possible opportunistic infections including opportunistic viral infections, but no meta analysis has ever focused on this issue. To evaluate whether there is an association between biological agents therapy(More)
BACKGROUND AND AIMS The incidence of Crohn's disease (CD) is increasing and has already become a refractory disorder in China. Data on extraintestinal manifestations (EIMs) in CD are rare, especially in Asians. We aimed to evaluate the trend of newly diagnosed CD and the prevalence and risk factors of EIMs in a clinical center in central China. MATERIALS(More)
BACKGROUND Growing evidence has shown that coagulation processes play an important role in disease pathogenesis and/or disease progression in patients with inflammatory bowel disease. However, no study has ever focused on the possible influence of infliximab (IFX) therapy on the coagulation status in patients with Crohn's disease (CD). OBJECTIVE To(More)
A 68-year-old man presented with the complaint of hematochezia for 2 months. The results of hematological examinations showed red blood cell count 2.43 × 1012/L, hemoglobin 4.86 g/dL, white blood cell count 3.99 × 109/L (including 11.5% eosinophil granulocyte) and positive pancreatic autoantibodies (PABs). Esophagogastroduodenoscopy (EGD), colonoscopy and(More)
This study aimed to investigate the role of JNK pathway-associated phosphatase (JKAP) in inflammatory bowel disease (IBD). JKAP expression was analyzed in the intestinal mucosa of 81 IBD patients and 25 healthy controls (HCs) by qPCR and immunoblotting. The correlations of JKAP with clinical activity and inflammatory cytokines were performed. JKAP(More)
Aiming at the comprehensive and seamless information integration of gas-making furnace, a resolution scheme of information integration in the special environment is given based on OPC technology after detailed analysis the superiority of monitor configuration software and OPC technology in the integration of information systems. In addition, a set of OPC(More)
BACKGROUND/AIMS To investigate the associations between the rs1250569 (zinc finger MIZ-type containing 1, ZMIZ1), rs1042522 (tumour protein p53, TP53), and rs10114470 (tumour necrosis factor-like cytokine 1A, TL1A) polymorphisms and the development of inflammatory bowel disease (IBD) in a Chinese (Han) population. We analysed the expression of genes that(More)
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