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Associations of Lys939Gln and Ala499Val polymorphisms of the XPC gene with cancer susceptibility: A meta‐analysis
- Jing He, Ting-Yan Shi, Mei-ling Zhu, Meng-Yun Wang, Qiaoxin Li, Q. Wei
- Biology, Medicine
- International journal of cancer
- 15 October 2013
Some solid statistical evidence is established for an association between XPC polymorphisms and cancer risk, which warrants further validation in single large studies, and significantly correlation between X PC genotypes and mRNA expression was found only for Asian populations. Expand
Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts.
- Hiroaki Sakai, Y. Chen, T. Itokawa, K. Yu, Mei-ling Zhu, K. Insogna
- Biology, Medicine
- 1 December 2006
Evidence is provided that the hemopoietic guanine nucleotide exchange factor, Vav, and its target GTPase, Rac, lie downstream from this initial signaling complex and that Rac is required for CSF-1-induced cytoskeletal remodeling in these cells. Expand
Genetic variations of mTORC1 genes and risk of gastric cancer in an eastern chinese population
The hypothesis that functional polymorphisms of mTOR may contribute to gastric cancer risk is supported, although these results require validation in larger studies with different ethnic populations. Expand
A pri-miR-218 variant and risk of cervical carcinoma in Chinese women
The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women and using the multifactor dimensionality reduction analysis observed some evidence of interactions of these two SNPs with other risk factors, especially age at primiparity and menopausal status. Expand
Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women
The IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression. Expand
Association between the ERCC5 Asp1104His Polymorphism and Cancer Risk: A Meta-Analysis
A meta-analysis of 44 published case-control studies suggests that it is unlikely that the ERCC5 Asp1104His polymorphism may contribute to individual susceptibility to cancer risk. Expand
Predictable factors for lymph node metastasis in early gastric cancer analysis of clinicopathologic factors and biological markers
Risk factors that predict the presence of LNM in early gastric cancer (EGC) and a significantly statistical association of P53, ki67, and b-catenin with an increased risk of L NM in EGC patients were explored. Expand
Association between EGFR exon 19 or exon 21 mutations and survival rates after first-line EGFR-TKI treatment in patients with non-small cell lung cancer.
- Haiying Jiang, Mei-ling Zhu, Yanfang Li, Qian Li
- Medicine, Biology
- Molecular and clinical oncology
- 1 September 2019
Following EGFR-TKI therapy, a better ORR, DCR, PFS and OS was observed in patients with EGFR deletions in exon 19 compared with those with an exon 21 mutation, indicating that the EGFR mutation status of patients with non-small cell lung cancer may predict the efficacy and prognosis of EGFR -TKI. Expand
Conventional stents versus stents loaded with (125)iodine seeds for the treatment of unresectable oesophageal cancer: a multicentre, randomised phase 3 trial.
In patients with unresectable oesophageal cancer, the insertion of an oesphageal stent loaded with (125)iodine seeds prolonged survival when compared with the inserted of a conventional covered self-expandable metallic stent. Expand
Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes.
In the absence of information on human papillomavirus (HPV) infection, the TNFAIP8-rs11064 SNP may function by affecting the affinity of miR-22 binding to the 3'-UTR of TN FAIP8 and regulating TNFAip8 expression, thus contributing to cervical cancer risk. Expand