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Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of the prominent roles is to regulate gene expression. A vast number of circular RNAs (circRNAs) have been identified, and some have been shown to function as microRNA sponges in animal cells. Here, we report a class of circRNAs associated with RNA polymerase II in human cells.(More)
In this study, we used both case-crossover and time-series analyses to assess the associations between size-fractionated particulate matter and asthma hospitalization among children 6-12 years old living in Toronto between 1981 and 1993. Specifically, we used exposures averaged over periods varying from 1 to 7 days to assess the effects of particulate(More)
Associations of gaseous air pollutants (including carbon monoxide, sulfur dioxide, nitrogen dioxide, and ozone) with asthma hospitalization, stratified by sex and socioeconomic status, were examined among children 6-12 years of age in Vancouver, British Columbia, Canada, between 1987 and 1998. Relative risks for an exposure increment corresponding to the(More)
OBJECTIVES The purpose of this study was to examine the association between ambient air pollution and hospitalization for respiratory infections among children who were younger than 15 years in Toronto during a 4-year period (1998-2001). METHODS Exposures averaged during periods that varied from 1 to 7 days were used to assess the effects of air(More)
1. The composition of microsporocyte nucleoli of maize with different chromosomal constitutions was studied by the analysis of absorption spectra obtained from an ultraviolet microspectrophotometer. 2. The presence of ribonucleic acids (RNA) and proteins in the nucleolus was confirmed by the presence of two broad and overlapping absorption peaks around 2637(More)
Consistent with the goals of a comprehensive carbohydrate sequencing strategy, we extend earlier reports to include the characterization of structural (constitutional) isomers. Protocols were developed around ion trap instrumentation providing sequential mass spectrometry (MSn) and supported with automation and related computational tools. These strategies(More)
RUNX3 is a functionally important component in transforming growth factor-beta (TGF-β) mediated signaling pathway. Epigenetic silencing expression of RUNX3, as well as aberrant cytoplasmic retention of RUNX3 protein are causely involved in gastric carcinogenesis. Here, we examined the expression of RUNX3 gene and protein in oral squamous cell carcinomas(More)
A pressurized CEC (pCEC) method with postcolumn detection cell had been developed for quantifying the lignans from Fructus schisandrae extracts. The effects of different experimental conditions, such as the ACN content of the mobile phase, the concentration and pH of the buffer, the applied voltage, and the supplementary pressure were studied. Five lignans(More)
OBJECTIVE To determine the burden of enteric fever through trends in morbidity and mortality, bacterial species and antimicrobial resistance in Guangxi, a southern, subtropical, coastal province of China with a disproportionally large burden of enteric fever. METHODS Data on morbidity and mortality caused by enteric fever between 1994 and 2004 were(More)
OBJECTIVE To study the prevalence of chronic rhinosinusitis and its risk factors among Canadians. STUDY DESIGN Complex survey design incorporating stratification, multiple stages of selection, and unequal probabilities of selection of respondents. METHODS We used the cross-sectional data from 73,364 subjects (34,241 male and 39,123 female subjects) 12(More)