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Rapidly increasing rates of hip fracture in Beijing, China
TLDR
The rate of hip fracture has been rising very rapidly in Beijing, China, and the burden of hip fractures may be shifting rapidly from the West to urbanizing areas of the East.
Tumor‐induced osteomalacia: An important cause of adult‐onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature
TLDR
99Tcm‐OCT imaging successfully localized the tumor in the overwhelming majority of patients, and successful removal of tumors leads to cure in most cases, but recurrence should be sought by long‐term follow‐up.
Three Novel Mutations of the PHEX Gene in Three Chinese Families with X-linked Dominant Hypophosphatemic Rickets
TLDR
The results suggest that PHEX gene mutations were responsible for XLH in these patients and these mutations may contribute to a higher serum FGF23 level.
Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: Effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism
TLDR
Two novel CYP19A1 missense mutations in an aromatase-deficient man are identified and shown great impact on recovering the impairments in the bone, lipid, liver and glucose metabolism, but fails to improve insulin resistance.
SOST polymorphisms and response to alendronate treatment in postmenopausal Chinese women with osteoporosis.
TLDR
The polymorphisms of SOST are genetic factors affecting bone health and response to alendronate in Chinese postmenopausal women.
The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study
TLDR
Serum &bgr;-CTX was significantly higher in postmenopausal women with sustained fracture or vertebral fracture, and P1NP levels were negatively correlated with BMD, while Vitamin D deficiency was highly prevalent in post menopausal women in Beijing.
Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors.
TLDR
Investigation of differential expression of Ki-67, galectin-3, fragile histidine triad gene, and parafibromin in PC, parathyroid adenoma (PA),Parathyroid hyperplasia (PH), and normal parathyro (NP) tissues suggested that loss of parafIBromin and overexpression of galectIn-3 and Ki- 67 might help to distinguish parathyoid carcinoma from other parathyrod tumors.
Generalized glucocorticoid resistance accompanied with an adrenocortical adenoma and caused by a novel point mutation of human glucocorticoid receptor gene.
TLDR
Generalized glucocorticoid resistance in this patient might be caused by a novel heterozygotic mutation in the ligand-binding domain of the GR alpha, partially caused by mutations in the human glucoc Corticoid receptor (hGR) gene.
The efficacy and tolerability of once-weekly alendronate 70 mg on bone mineral density and bone turnover markers in postmenopausal Chinese women with osteoporosis
TLDR
It is concluded that once-weekly alendronate 70 mg is an effective and well-tolerated agent for the treatment of postmenopausal osteoporosis in Chinese women.
Novel mutations of CYP27B1 gene lead to reduced activity of 1α-hydroxylase in Chinese patients.
TLDR
Nine novel mutations in addition to 37 known mutations of CYP27B1 gene are described and the correlation between these mutations and the clinical findings of 1α-hydroxylase deficiency is shown.
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