Mei-Lan Chu

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The advantages of high-resolution diffusion tensor imaging (DTI) have been demonstrated in a recent post-mortem human brain study (Miller et al., NeuroImage 2011;57(1):167-181), showing that white matter fiber tracts can be much more accurately detected in data at a submillimeter isotropic resolution. To our knowledge, in vivo human brain DTI at a(More)
PURPOSE A projection onto convex sets reconstruction of multiplexed sensitivity encoded MRI (POCSMUSE) is developed to reduce motion-related artifacts, including respiration artifacts in abdominal imaging and aliasing artifacts in interleaved diffusion-weighted imaging. THEORY Images with reduced artifacts are reconstructed with an iterative projection(More)
PURPOSE To develop new techniques for reducing the effects of microscopic and macroscopic patient motion in diffusion imaging acquired with high-resolution multishot echo-planar imaging. THEORY The previously reported multiplexed sensitivity encoding (MUSE) algorithm is extended to account for macroscopic pixel misregistrations, as well as motion-induced(More)
Functional magnetic resonance imaging (fMRI) is a non-invasive and powerful imaging tool for detecting brain activities. The majority of fMRI studies are performed with single-shot echo-planar imaging (EPI) due to its high temporal resolution. Recent studies have demonstrated that, by increasing the spatial-resolution of fMRI, previously unidentified(More)
It is often required to map the radiances of a real scene to a smaller dynamic range so that the image can be properly displayed. However, most such algorithms suffer from the halo artifact or require manual parameter tweaking that is often a tedious process for the user. We propose an automatic algorithm for high dynamic range compression based on the(More)
PURPOSE Current four dimensional magnetic resonance imaging (4D-MRI) techniques lack sufficient temporal/spatial resolution and consistent tumor contrast. To overcome these limitations, this study presents the development and initial evaluation of a new strategy for 4D-MRI which is based on retrospective k-space reordering. METHODS We simulated a k-space(More)
Major advances in resting-state functional magnetic resonance imaging (fMRI) techniques in the last two decades have provided a tool to better understand the functional organization of the brain both in health and illness. Despite such developments, characterizing regulation and cerebral representation of mind wandering, which occurs unavoidably during(More)
PURPOSE Objects falling outside of the true elliptical field-of-view (FOV) in Propeller imaging show unique aliasing artifacts. This study proposes a de-aliasing approach to restore the signal intensities in Propeller images without extra data acquisition. MATERIALS AND METHODS Computer simulation was performed on the Shepp-Logan head phantom deliberately(More)
PURPOSE To develop a high-speed T2 mapping protocol that is capable of accurately measuring T2 relaxation time constants from a single-shot acquisition. THEORY A new echo-split single-shot gradient-spin-echo (GRASE) pulse sequence is developed to acquire multicontrast data while suppressing signals from most nonprimary echo pathways in(More)
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