Mehul P. Patel

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Histone methyltransferases (HMT) catalyze the methylation of histone tail lysines, resulting in changes in gene transcription. Misregulation of these enzymes has been associated with various forms of cancer, making this target class a potential new area for the development of novel chemotherapeutics. EZH2 is the catalytic component of the polycomb group(More)
Epigenetic gene regulation is a critical process controlling differentiation and development, the malfunction of which may underpin a variety of diseases. In this article, we review the current landscape of small-molecule epigenetic modulators including drugs on the market, key compounds in clinical trials, and chemical probes being used in epigenetic(More)
Beta-ketoacyl-acyl carrier protein reductase (KACPR) catalyzes the NADPH-dependent reduction of beta-ketoacyl-acyl carrier protein (AcAc-ACP) to generate (3S)-beta-hydroxyacyl-ACP during the chain-elongation reaction of bacterial fatty acid biosynthesis. We report the evaluation of the kinetic and chemical mechanisms of KACPR using acetoacetyl-CoA(More)
Turbulent flow separation over a wall-mounted hump model and its control using plasma actuators were studied numerically and experimentally. The hump model chosen in this study was that used in a 2004 NASA Langley CFD validation workshop for turbulent separation control using synthetic jets. The numerical simulations solved the Reynoldsaveraged(More)
This paper presents an innovative Plasma Aerodynamic Control Effectors (PACE) concept for improved performance of wind turbines. The concept is aimed towards the design of “smart” wind turbine blades with integrated sensor-actuator-controller modules to improve the performance of wind turbines. The system will be designed to enhance energy capture, and(More)
A series of 3-phenyl-2-propenamides discovered from a high-throughput screening campaign as novel, potent, glucose-sensitive inhibitors of human liver glycogen phosphorylase a is described. A solid-phase synthesis on DMHB resin was also developed which provided efficient access not only to certain analogues that could not be cleanly made using more(More)
Introduction A proof-of-concept closed-loop reactive flow control Combat arenas in the near future will require methodology using discrete intelligent control modules unprecedented levels of performance from air vehicles for virtual aerodynamic shaping of air vehicles is to meet mission-specific objectives. Future air vehicles developed. Discrete suction(More)
A series of amino acid anthranilamide derivatives identified from a high-throughput screening campaign as novel, potent, and glucose-sensitive inhibitors of human liver glycogen phosphorylase a are described. A solid-phase synthesis using Wang resin was also developed which provided efficient access to a variety of analogues, and resulted in the(More)
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