Mehrdad Shariati

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In spite of previous reports, the role of transforming growth factor-β1 (TGF-β1) on cardiomyocyte differentiation, especially in the present autologous serum (AS) in culture medium, is still unclear. So, the purpose of this study was to investigate the potential of rat bone marrow mesenchymal stem cells (rBMSCs) to proliferate and differentiate towards(More)
This paper focuses on the development of renewable sources of isletreplacement tissue for the treatment of type I diabetes mellitus. Placental tissue-derived mesenchymal stem cells (MSCs) are a promising source for regenerative medicine due to their plasticity and easy availability. They have the potential to differentiate into insulin-producing cells.(More)
BACKGROUND Mesenchymal stem cells (MSCs) possess a wide range of immunomodulatory functions mostly in immune cells including dendritic cells (DCs). DCs are the key cells in the immune response and play an important role in initiating cell-mediated immunity. OBJECTIVE To evaluate the immunomodulatory effects of MSCs supernatant on maturation and function(More)
OBJECTIVES In diabetes mellitus type 1, beta cells are mostly destroyed; while in diabetes mellitus type 2, beta cells are reduced by 40% to 60%. We hope that soon, stem cells can be used in diabetes therapy via pancreatic beta cell replacement. Induced pluripotent stem cells are a kind of stem cell taken from an adult somatic cell by "stimulating" certain(More)
Background: Considering the importance of Trazodone as a serotonin antagonist reuptake inhibitor in treating nervous diseases, its side effects on the endocrine axis are extremely important. Objective: In this research the effect of Trazodone on the concentration of testosterone, FSH and LH levels and spermatogenesis were studied. Materials and Methods: 40(More)
Background: Myrtus communis leaves have the potential to affect thyroid hormone functions. Objectives: In this study, the effects of hydroalcoholic extract of M. communis on the hypothalamus-pituitary-thyroid axis and histological changes were studied. Materials and Methods: In this experimental study, 40 male rats were divided in 5 groups (n = 8): control,(More)
Pregabalin binds potently to the α2-δ subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noraderenaline, serotonin, dopamine and substance P. Recently it is approved for adjunctive treatment of partial seizures in adults neuropathic pain from postherpetic neuralgia and diabetic neuropathy.(More)
The umbilical cord is a rich source of stem cells with high proliferation and differentiation capabilities (Weiss & Troyer, 2006). Wharton’s jelly is the conne cti ve tissue of the umbilical cord lying between the am niotic epithelium and the umbilical vessels (Tag hi za deh et al., 2011). Several protocols have been reported for isolation, culture and(More)
OBJECTIVE(S) Leptin is a hormone secreted by adipose tissue and is involved not only in the regulation of feeding and energy expenditure, but also its role in memory enhancement has been demonstrated as well. The partial transfer of leptin across the blood-brain barrier in obese individuals causes leptin resistance and prevents leptin reaching brain. On the(More)
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