Mehrdad Mohammadi

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BACKGROUND Alzheimer's disease is characterized by a slow, progressive decline in cognitive function and behaviour. Acetylcholine esterase inhibitors are the only agents approved by the Food and Drug Administration for the treatment of Alzheimer's disease. All other agents prescribed for the treatment of Alzheimer's disease are used on an off-label basis.(More)
OBJECTIVE To assess the efficacy and safety of Melissa officinalis extract using a fixed dose (60 drops/day) in patients with mild to moderate Alzheimer's disease. DESIGN A four month, parallel group, placebo controlled trial undertaken in three centres in Tehran, Iran. METHODS Patients with mild to moderate Alzheimer's disease aged between 65 and 80(More)
OBJECTIVE Autism is a childhood-onset disorder of unknown, possibly of multiple aetiologies. The core symptoms of autism are abnormalities in social interaction, communication and behaviour. The involvement of neurotransmitters such as 5-HT has been suggested in neuropsychiatric disorders and particularly in autistic disorder. Increased platelet 5-HT levels(More)
As Human Genome Project exploration continues, the necessity of having a broader spectrum of genomic DNA material from different nationalities to study various aspects of hereditary disease becomes more obvious. The existence of high genetic polymorphism within and between different communities in the world makes it necessary for the gene hunters to(More)
OBJECTIVE There is growing interest in investigating the role of 5-HT receptors in the physiopathology of schizophrenia in particular the negative symptoms. Indeed, newer atypical antipsychotics which interact with 5-HT receptors are more effective in the treatment of negative symptoms compared to typical neuroleptics. We undertook a trial to investigate(More)
Application of therapeutic gene transfer in the treatment of genetic diseases is a notable progress but there are some disadvantages and limitations in it. The process of overcoming these barriers is a drastic change in gene delivery. Recently, calcium phosphate nanoparticles alone, or in combination with viral and nonviral vectors, were found to have a(More)
Department of Industrial Engineering, Center of Excellence for Intelligent Experimental Mechanics, College of Engineering, University of Tehran, P.O. Box 11365-4563, Iran Department of Industrial Engineering, Faculty of Engineering, University of Tafresh, Iran Department of Industrial Engineering, Faculty of Engineering, Iran University of Science and(More)
In this paper, a new priority M/M/c queuing hub covering problem is presented, in which products with high priority are selected for service ahead of those with low priority. In addition, a mixed-integer nonlinear mathematical programming model is presented to find a good solution of the given problem. Due to its computational complexity, we propose a(More)
Cystinuria is an autosomal inherited disorder of renal reabsorption of cystine, arginine, lysine, and ornithine. Increased urinary excretion of cystine results in the formation of kidney stones. Considering the few studies on the genetic basis of the cystinuria in the Middle East and the population-specific distribution of mutations in the SLC3A1 and SLC7A9(More)
Recent research is recognizing that multiple criteria analysis should take account of the concepts of uncertainty and risk. In some cases, precise determination of the exact value of alternatives and weights of criteria is difficult. Consequently, to deal with these potential problems, their values are regarded as fuzzy and intervals. This paper proposes an(More)