Mehmet Veysel Yigit

Learn More
Recent progress in an emerging area of designing aptamer and nanomaterial conjugates as molecular diagnostic and drug delivery agents in biomedical applications is summarized. Aptamers specific for a wide range of targets are first introduced and compared to antibodies. Methods of integrating these aptamers with a variety of nanomaterials, such as gold(More)
Design of smart MRI contrast agent based on superparamagnetic iron oxide nanoparticles and aptamers has been described for the detection of human alpha-thrombin protein. The contrast agent is based on the assembly of the aptamer functionalized nanoparticles in the presence of thrombin. A detectable change in MRI signal is observed with 25 nM thrombin in(More)
2 ACKNOWLEDGEMENTS : 3 TABLE OF CONTENTS : 4 LIST OF FIGURES : 5 LIST OF TABLES : 8 INTRODUCTION : 9 RESULT and DISCUSSION : 37 Layers from 2,4,6-Pyridinetricarboxylic Acid, Imidazole, and First-row Transition Metals : 37 Mixed Crystals : 56 Composite Crystals : 63 CONCLUSION : 83 EXPERIMENTAL SECTION : 84 General Techniques : 84 Synthesis of(More)
A liposome system that can detect and detoxify mercury in aqueous solution is demonstrated. The system consists of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine and 20% PEG-PE (PEG MW 2000 Da) that forms liposome, which encapsulates self-quenching fluorescein for detection, and chelating agent meso-2,3-dimercaptosuccinic acid (meso-DMSA) for chelating(More)
  • 1