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In most deterministic manufacturing decision models, demand is either known or induced by pricing decisions in the period that the demand is experienced. However, in more realistic market scenarios consumers make purchase decisions with respect to price, not only in the current period, but also in past and future periods. We model a joint(More)
The risk of supply disruption increases as firms seek to procure from cheaper, but unproven, suppliers. We model a supply chain consisting of a single buyer and two suppliers, both of whom compete for the buyer's order and face risk of supply disruption. One supplier is comparatively more reliable but also more expensive, while the other unreliable one is(More)
A significant and growing volume of global trade travels on container ships, and each year larger ships are introduced. For this reason, the Container Stowage Problem, a fundamental problem in marine cargo transportation involving the optimal assignment of shipping containers of various types to specific storage locations in container ship at each port in(More)
W e introduce and analyze a model that explicitly considers the timing effect of intertemporal pricing— the concept, found in practice, that demand during a sale is increasing in the time since the last sale. We present structural results that characterize the interaction between the decision to hold a sale and the inventory-ordering decision. We show that(More)
We study a single-resource multi-class revenue management problem where the resource consumption for each class is random and only revealed at departure. The model is motivated by cargo revenue management problems in the airline and other shipping industries. We study how random resource consumption distribution affects the optimal expected profit and(More)
We have synthesized ethyl (2E)-3-amino-2-({[(4-benzoyl-1,5-diphenyl-1H-pyrazol-3-yl)carbonyl]amino}carbonothioyl)but-2-enoate (2) by the reaction of 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carbonyl chloride (1), ammonium thiocyanate and ethyl 3-aminobut-2-enoate and then characterized by elemental analyses, IR, Raman, (1)H NMR, (13)C NMR and X-ray diffraction(More)
Inhibition of the Hsp90 function is an essential therapeutic approach and several inhibitors were designed as anti-cancer agents. These inhibitors are ATPases and they aim to deregulate Hsp90 folding function. ATPase proteins are common in human metabolism but they form nonspecific targets. Hsp90 functions as dimer with coordinating chaperones. Heat Shock(More)
We consider the joint pricing and inventory control problem for a single product whose demand distribution in each period is determined both by whether or not a sale price is offered in the current period, and the number of periods since the last time the sale price was offered. We show that optimal inventory ordering policy is a state dependent base stock(More)