Mehdi Asghari-Khiavi

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To gain more understanding into the mechanism that enables the dramatic resonant Raman enhancement of totally symmetric modes observed in hemozoin (malaria pigment) and other related heme supramolecular arrays when applying near-infrared excitation wavelengths, the iron(III) porphyrins Fe(TPP)Cl, [Fe(TPP)](2)O, Fe(OEP)Cl, and [Fe(OEP)](2)O along with(More)
The effects of fixation and dehydration on the distribution of heme-based molecules inside red blood cells and the structural integrity of the cells have been investigated using Raman mapping and AFM topographic imaging. A strong correlation was observed between the thickness of the cells as determined from AFM images and the intensity of the characteristic(More)
Hemoglobin nanocrystals were analyzed with tip-enhanced Raman scattering (TERS), surface-enhanced resonance Raman scattering (SERRS) and conventional resonance Raman scattering (RRS) using 532 nm excitation. The extremely high spatial resolution of TERS enables selective enhancement of heme, protein, and amino acid bands from the crystal surface not(More)
The equilibrium solubilities of three drugs (phenazopyridine, propranolol and methimazole) were determined at temperatures ranging from 308 to 348 K and pressures from 122 to 355 bar in supercritical CO2 by a simple and reliable static method. The crossover region was observed for phenazopyridine, propranolol and methimazole at 180 bar. The solubilities(More)
Feasibility of supercritical CO(2) extractions of two steroid drugs, medroxyprogesterone acetate (med) and cyproterone acetate (cyp), were evaluated. The effects of temperature (308-348 K), pressure (100-300 bar), static extraction time (5-15 min), dynamic extraction time (10-30 min) and percent methanol modifier (1-10% v/v) on the SFE recoveries of these(More)
The geometrical parameters and static electric properties of several metal porphyrin halides, including Fe(III) porphine chloride (FePCl), Fe(III) porphine bromide (FePBr), Fe(III) tetraphenylporphine chloride (FeTPPCl), aluminum phthalocyanine chloride (AlPcCl), gallium(III) phthalocyanine chloride (GaPcCl), and manganese(III) phthalocyanine chloride(More)
Information theory and, specifically, Shannon's measure of information is used to compare the interaction parameters (beta) in regular solution theory (RST) and Ingram's model for the mixture of cetyltrimethylammonium bromide (CTAB) and Triton X-100 (TX100). Results show that beta values from regular solution theory are more accurate than those of Ingram's(More)
The solvent-induced changes in the optical and spectroscopic properties of 1,2-benzenedicarboxylic anhydride are studied using time dependent Hartree-Fock and density functional theory calculations within the framework of two reaction field procedures. To investigate the influence of the cavity shape, the Onsager reaction field is compared with the(More)
To investigate the nature of binding of quinoline antimalarial drugs to heme and to extract experimental evidence for this binding, the interaction of ferriprotoporphyrin IX (FP) with chloroquine and quinacrine (both of which have a similar side chain) and quinoline methanol antimalarials quinine and mefloquine has been studied using IR and NIR-Raman(More)
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